Characterization of a daptomycin-nonsusceptible vancomycin-intermediate Staphylococcus aureus strain in a patient with endocarditis

Kathleen Julian, Klaudia Kosowska-Shick, Cynthia Whitener, Martin Roos, Harald Labischinski, Aileen Rubio, Leslie Parent, Lois Ednie, Laura Koeth, Tatiana Bogdanovich, Peter C. Appelbaum

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

We analyzed the emergence of daptomycin nonsusceptibility in a patient with persistent vancomycin-intermediate Staphylococcus aureus (VISA) bacteremia. The daptomycin-nonsusceptible VISA'S cell wall demonstrated a reduction in muramic acid O-acetylation, a phenotypic parameter not previously reported for VISA; some isolates also contained a single point mutation in the mprF gene.

Original languageEnglish (US)
Pages (from-to)3445-3448
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number9
DOIs
StatePublished - Sep 2007

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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