Characterization of ACTH mediated suppression of MHC class II expression by murine peritoneal macrophages

Bruce S. Zwilling, William P. Lafuse, David Brown, Dennis Keith Pearl

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The effect of ACTH on the expression of major histocompatibility complex (MHC) class II (I-A) glycoprotein by murine peritoneal macrophages was evaluated. ACTH suppressed the expression of I-A by macrophages in a time- and dose-dependent manner. ACTH mediated its effect by decreasing the level of I-A mRNA. ACTH suppressed the expression of I-A by macrophages from mice that are susceptible to the in vivo growth of mycobacteria but did not affect the expression of I-A by macrophages from Mycobacterium bovis strain (BCG)-resistant mice. The concentrations of ACTH required to suppress I-A expression were greater than that required for an effect on adrenal steroid production and may be related to the localized production of ACTH by lymphocytes and macrophages.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalJournal of Neuroimmunology
Volume39
Issue number1-2
DOIs
StatePublished - Jan 1 1992

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Characterization of ACTH mediated suppression of MHC class II expression by murine peritoneal macrophages'. Together they form a unique fingerprint.

  • Cite this