Characterization of the avian Ich-1 cDNA and expression of Ich-1(L) mRNA in the hen ovary

A. L. Johnson, J. T. Bridgham, L. Bergeron, J. Yuan

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

We have sequenced the chicken interleukin-1β-converting enzyme (ICE) and ced-3 homolog (Ich-1) cDNA, and evaluated Ich-1 mRNA expression in the hen ovary during follicle development. While two alternatively spliced forms of Ich-1, Ich-1(L) and Ich-1(S), were amplified by PCR from an embryonic chicken cDNA library, only the Ich-1(L) form was found to be expressed in adult ovarian granulosa and theca tissues. The deduced amino acid (aa) sequence of ICH-1(L) is 70.8% identical to human ICH-1(L) and contains the conserved QACRG peptide active catalytic sequence characteristic of many ICE-related family of cysteine proteases.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalGene
Volume192
Issue number2
DOIs
StatePublished - Jun 19 1997

All Science Journal Classification (ASJC) codes

  • Genetics

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