Chediak-higashi syndrome in pregnancy

Fredric V. Price, Richard S. Legro, Margaret Watt-Morse, Sandra S. Kaplan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We report the first known case of Chediak-Higashi syndrome in human pregnancy. This rare autosomal recessive disorder is characterized by partial oculocutaneous albinism, decreased leukocyte chemotaxis, susceptibility to infection, and death in childhood. Pathognomonic giant cytoplasmic granules are postulated to be dysfunctional fused lysosomes, which influence a wide range of physiologic processes. Pregnancy did not seem to exert any influence on the course of the disease. The pregnancy, labor, and delivery were not affected and the infant and placenta were normal. (Obstet Gynecol 1992;79:8046)

Original languageEnglish (US)
Pages (from-to)804-806
Number of pages3
JournalObstetrics and gynecology
Volume79
Issue number5
StatePublished - May 1992

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

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