Chediak Higashi syndrome: reversal of increased susceptibility to infection by bone marrow transplantation

J. A. Kazmierowski, R. J. Elin, Herbert Reynolds, W. A. Durbin, S. M. Wolff

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Transplantation of normal bone marrow to mice with the Chediak Higashi syndrome (CHS) resulted in normal granulopoiesis and a reversal of their increased susceptibility to challenge with intravenous Candida albicans. These findings suggest that the leukocyte defect in CHS can be reversed by marrow transplantation and that the mechanism for increased susceptibility to infection in these animals is due to a bone marrow derived cellular defect. Because of similarities between murine and human CHS, bone marrow transplantation might be considered as a mode of therapy in selected cases of the human disease.

Original languageEnglish (US)
Pages (from-to)555-559
Number of pages5
JournalBlood
Volume47
Issue number4
StatePublished - Dec 1 1976

Fingerprint

Chediak-Higashi Syndrome
Bone Marrow Transplantation
Bone
Infection
Bone Marrow
Defects
Candida
Candida albicans
Animals
Leukocytes
Transplantation
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Kazmierowski, J. A., Elin, R. J., Reynolds, H., Durbin, W. A., & Wolff, S. M. (1976). Chediak Higashi syndrome: reversal of increased susceptibility to infection by bone marrow transplantation. Blood, 47(4), 555-559.
Kazmierowski, J. A. ; Elin, R. J. ; Reynolds, Herbert ; Durbin, W. A. ; Wolff, S. M. / Chediak Higashi syndrome : reversal of increased susceptibility to infection by bone marrow transplantation. In: Blood. 1976 ; Vol. 47, No. 4. pp. 555-559.
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Kazmierowski, JA, Elin, RJ, Reynolds, H, Durbin, WA & Wolff, SM 1976, 'Chediak Higashi syndrome: reversal of increased susceptibility to infection by bone marrow transplantation', Blood, vol. 47, no. 4, pp. 555-559.

Chediak Higashi syndrome : reversal of increased susceptibility to infection by bone marrow transplantation. / Kazmierowski, J. A.; Elin, R. J.; Reynolds, Herbert; Durbin, W. A.; Wolff, S. M.

In: Blood, Vol. 47, No. 4, 01.12.1976, p. 555-559.

Research output: Contribution to journalArticle

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Kazmierowski JA, Elin RJ, Reynolds H, Durbin WA, Wolff SM. Chediak Higashi syndrome: reversal of increased susceptibility to infection by bone marrow transplantation. Blood. 1976 Dec 1;47(4):555-559.