Chediak Higashi syndrome: reversal of increased susceptibility to infection by bone marrow transplantation

J. A. Kazmierowski, R. J. Elin, H. Y. Reynolds, W. A. Durbin, S. M. Wolff

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Transplantation of normal bone marrow to mice with the Chediak Higashi syndrome (CHS) resulted in normal granulopoiesis and a reversal of their increased susceptibility to challenge with intravenous Candida albicans. These findings suggest that the leukocyte defect in CHS can be reversed by marrow transplantation and that the mechanism for increased susceptibility to infection in these animals is due to a bone marrow derived cellular defect. Because of similarities between murine and human CHS, bone marrow transplantation might be considered as a mode of therapy in selected cases of the human disease.

Original languageEnglish (US)
Pages (from-to)555-559
Number of pages5
JournalUnknown Journal
Volume47
Issue number4
DOIs
StatePublished - 1976

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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