Polybrominated dibenzopdioxins and dibenzofurans have been identified as potential environmental contaminants. The present studies were designed to characterize the chemical disposition of a tetrabrominated dibenzofuran. The isomerspecific pattern of 1, 2, 7, 8-tetrabromodibenzofuran (TBDF) was chemically characterized using highpressure liquid chromatography, gas chromatography/mass spectrometry, infrared absorption, and proton nuclear magnetic resonance techniques. The absorption, distribution, and elimination of 1, 2, 7, 8-[4, 6-3H]TBDF were examined in the rat following a single oral, dermal, or intravenous dose of 1 nmol/kg. The 1, 2, 7, 8-TBDF was rapidly excreted in the bile (-50% of the dose in 8 h). Likewise, over half of the administered dose was found in the feces and intestine contents 24 h after iv administration and in feces 72 h after oral administration. Thus, the halflife of 1, 2, 7, 8-TBDF is approximately I d. Major tissue depots included the.
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