Chemo-mechanically regulated oscillation of an enzymatic reaction

Ximin He, Ronn S. Friedlander, Lauren D. Zarzar, Joanna Aizenberg

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Biochemical reactions would open doors to the control of innumerable sophisticated, environmentally friendly, enzymatic, or other biological activities useful for self-regulating medical implants, such as biomolecule detection, separation, and signal amplification. Biochemical processes in general are typically sensitive to pH, temperature, and salt concentrations, requiring a narrow range to operate successfully. The rapid responsiveness and precise synchronization of the light emission and the microfin movement in and out of the reagent layer during multiple cycles are well evidenced by the time-resolved bioluminescence intensity. The proper function of the enzyme is further supported by the sustained luminescence through 30-40 actuation cycles. The SMARTS device is shown to be both compatible with delicate biological constraints and capable of accommodating enzymatic reactions for signal transduction, attributed to its modularity, tunability, and physical simplicity.

Original languageEnglish (US)
Pages (from-to)521-523
Number of pages3
JournalChemistry of Materials
Volume25
Issue number4
DOIs
StatePublished - Feb 26 2013

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry

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