Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNγ-producing effector cells

Peter A. Calabresi, Sung Hae Yun, Rameeza Allie, Katharine A. Whartenby

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compared these profiles to those of TCL-generated in response to tetanus toxoid (TT). Expression of CXCR6 and CXCR3 on TCL was significantly positively correlated with IFNγ, and inversely correlated with IL-5 production. TT TCL had significantly higher expression of CCR7-/CD45RA- T effector memory (Tem) cells than MBP TCL. However, in MBP-specific TCL, CXCR6 was found to be the best marker of conversion to the Tem phenotype. CXCR6 and CXCR3 are likely to be important in the migration of effector memory T cells in Th1-mediated inflammatory diseases such as multiple sclerosis (MS).

Original languageEnglish (US)
Pages (from-to)96-105
Number of pages10
JournalJournal of Neuroimmunology
Volume127
Issue number1-2
DOIs
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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