TY - JOUR
T1 - Chemokine receptor expression on MBP-reactive T cells
T2 - CXCR6 is a marker of IFNγ-producing effector cells
AU - Calabresi, Peter A.
AU - Yun, Sung Hae
AU - Allie, Rameeza
AU - Whartenby, Katharine A.
PY - 2002
Y1 - 2002
N2 - Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compared these profiles to those of TCL-generated in response to tetanus toxoid (TT). Expression of CXCR6 and CXCR3 on TCL was significantly positively correlated with IFNγ, and inversely correlated with IL-5 production. TT TCL had significantly higher expression of CCR7-/CD45RA- T effector memory (Tem) cells than MBP TCL. However, in MBP-specific TCL, CXCR6 was found to be the best marker of conversion to the Tem phenotype. CXCR6 and CXCR3 are likely to be important in the migration of effector memory T cells in Th1-mediated inflammatory diseases such as multiple sclerosis (MS).
AB - Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compared these profiles to those of TCL-generated in response to tetanus toxoid (TT). Expression of CXCR6 and CXCR3 on TCL was significantly positively correlated with IFNγ, and inversely correlated with IL-5 production. TT TCL had significantly higher expression of CCR7-/CD45RA- T effector memory (Tem) cells than MBP TCL. However, in MBP-specific TCL, CXCR6 was found to be the best marker of conversion to the Tem phenotype. CXCR6 and CXCR3 are likely to be important in the migration of effector memory T cells in Th1-mediated inflammatory diseases such as multiple sclerosis (MS).
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UR - http://www.scopus.com/inward/citedby.url?scp=0036270978&partnerID=8YFLogxK
U2 - 10.1016/S0165-5728(02)00106-6
DO - 10.1016/S0165-5728(02)00106-6
M3 - Article
C2 - 12044980
AN - SCOPUS:0036270978
VL - 127
SP - 96
EP - 105
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -
