Chemoprevention of breast cancer by fish oil in preclinical models: Trials and tribulations

Carina Signori, Karam El-Bayoumy, Jose Russo, Henry J. Thompson, John P. Richie, Terryl J. Hartman, Andrea Manni

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Despite the perception that omega-3 fatty acids (n-3 FA) protect against breast cancer, epidemiologic studies have yielded inconsistent results. Although preclinical data have been, in general, more supportive of a protective effect of n-3 FA on breast cancer, inconsistencies still remain, which preclude definite conclusions or in-depth mechanistic investigations despite 30 years of research in this area. In this review, we discuss key variables that may account for inconsistencies of results across preclinical studies and provide recommendations for future experiments testing the chemopreventive effect of n-3 FAs in breast cancer, as part of a multiagent approach under rigorously controlled conditions.

Original languageEnglish (US)
Pages (from-to)6091-6096
Number of pages6
JournalCancer Research
Volume71
Issue number19
DOIs
StatePublished - Oct 1 2011

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this