Chemoprevention of Melanoma

Subba Rao V. Madhunapantula, Gavin Robertson

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Citations (Scopus)

Abstract

Despite advances in drug discovery programs and molecular approaches for identifying drug targets, incidence and mortality rates due to melanoma continue to rise at an alarming rate. Existing preventive strategies generally involve mole screening followed by surgical removal of the benign nevi and abnormal moles. However, due to lack of effective programs for screening and disease recurrence after surgical resection, there is a need for better chemopreventive agents. Although sunscreens have been used extensively for protecting from UV-induced melanomas, results of correlative population-based studies are controversial, with certain studies suggest increased skin cancer risk in sunscreen users. Therefore, these studies require further authentication to conclusively confirm the chemoprotective efficacy of sunscreens. This chapter reviews the current understanding regarding melanoma chemoprevention and the various strategies used to accomplish this objective.

Original languageEnglish (US)
Title of host publicationAdvances in Pharmacology
PublisherAcademic Press Inc.
Pages361-398
Number of pages38
DOIs
StatePublished - Jan 1 2012

Publication series

NameAdvances in Pharmacology
Volume65
ISSN (Print)1054-3589
ISSN (Electronic)1557-8925

Fingerprint

Sunscreening Agents
Chemoprevention
Melanoma
Nevus
Skin Neoplasms
Drug Discovery
Recurrence
Mortality
Incidence
Pharmaceutical Preparations
Population

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Madhunapantula, S. R. V., & Robertson, G. (2012). Chemoprevention of Melanoma. In Advances in Pharmacology (pp. 361-398). (Advances in Pharmacology; Vol. 65). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-397927-8.00012-9
Madhunapantula, Subba Rao V. ; Robertson, Gavin. / Chemoprevention of Melanoma. Advances in Pharmacology. Academic Press Inc., 2012. pp. 361-398 (Advances in Pharmacology).
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Madhunapantula, SRV & Robertson, G 2012, Chemoprevention of Melanoma. in Advances in Pharmacology. Advances in Pharmacology, vol. 65, Academic Press Inc., pp. 361-398. https://doi.org/10.1016/B978-0-12-397927-8.00012-9

Chemoprevention of Melanoma. / Madhunapantula, Subba Rao V.; Robertson, Gavin.

Advances in Pharmacology. Academic Press Inc., 2012. p. 361-398 (Advances in Pharmacology; Vol. 65).

Research output: Chapter in Book/Report/Conference proceedingChapter

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AB - Despite advances in drug discovery programs and molecular approaches for identifying drug targets, incidence and mortality rates due to melanoma continue to rise at an alarming rate. Existing preventive strategies generally involve mole screening followed by surgical removal of the benign nevi and abnormal moles. However, due to lack of effective programs for screening and disease recurrence after surgical resection, there is a need for better chemopreventive agents. Although sunscreens have been used extensively for protecting from UV-induced melanomas, results of correlative population-based studies are controversial, with certain studies suggest increased skin cancer risk in sunscreen users. Therefore, these studies require further authentication to conclusively confirm the chemoprotective efficacy of sunscreens. This chapter reviews the current understanding regarding melanoma chemoprevention and the various strategies used to accomplish this objective.

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Madhunapantula SRV, Robertson G. Chemoprevention of Melanoma. In Advances in Pharmacology. Academic Press Inc. 2012. p. 361-398. (Advances in Pharmacology). https://doi.org/10.1016/B978-0-12-397927-8.00012-9