Chemoreflexes: An experimental study

Benjamin B.Y. Chiang, Andrew M. Roberts, Abul M. Kashem, William P. Santamore, Sufan Chien, Laman Gray, Robert Dowling

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hypothesis: Transmyocardial laser revascularization (TMLR) will not denervate the heart, because it does not destroy all of the afferents. This study was designed to determine if stimulation of cardiac sympathetic and vagal afferents from an area of the left ventricle treated with TMLR could evoke reflex effects, and thus whether TMLR would denervate the heart. Methods: The effect of TMLR on reflexes evoked by chemically stimulating cardiac afferents was examined in 9 dogs. Bradykinin and capsaicin were applied topically or injected into the left anterior descending coronary artery before and after TMLR and after bilateral vagotomy and sympathectomy. Aortic (AoP) and left ventricular pressures (LVP) and electrocardiography were monitored. The first derivatives of LVP (dP/dt) were calculated. Results: Topical bradykinin elicited variable hemodynamic responses. Topical capsaicin evoked pressor responses, increasing mean (± SEM) AoP (105±9 to 115±9 mm Hg; P<.001) and positive dP/dt (+dP/dt) (1032±81 to 1159±10 mm Hg/s; P<.01) before TMLR. Intracoronary capsaicin evoked a depressor response before TMLR. Pressor responses remained intact after TMLR with increases in mean AoP and +dP/dt (115±6 to 128±5 mm Hg and 1039±98 to 1136±100 mm Hg/s, respectively; P<.01). Depressor responses also remained intact after TMLR (91±10 vs 101±11 mm Hg [P<.02], and 865±104 vs 931±104 mm Hg/s [P<.05], respectively). Hemodynamic responses were diminished after bilateral vagotomy and abolished after bilateral sympathectomy. Conclusion: Since activation of cardiac afferent nerves and reflex responses remained intact after TMLR, but changed after vagotomy or sympathectomy, TMLR does not denervate the heart sufficiently to be the cause of improved angina after TMLR.

Original languageEnglish (US)
Pages (from-to)577-581
Number of pages5
JournalArchives of Surgery
Volume135
Issue number5
DOIs
StatePublished - May 2000

Fingerprint

Transmyocardial Laser Revascularization
Sympathectomy
Vagotomy
Capsaicin
Reflex
Bradykinin
Ventricular Pressure
Hemodynamics

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Chiang, B. B. Y., Roberts, A. M., Kashem, A. M., Santamore, W. P., Chien, S., Gray, L., & Dowling, R. (2000). Chemoreflexes: An experimental study. Archives of Surgery, 135(5), 577-581. https://doi.org/10.1001/archsurg.135.5.577
Chiang, Benjamin B.Y. ; Roberts, Andrew M. ; Kashem, Abul M. ; Santamore, William P. ; Chien, Sufan ; Gray, Laman ; Dowling, Robert. / Chemoreflexes : An experimental study. In: Archives of Surgery. 2000 ; Vol. 135, No. 5. pp. 577-581.
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Chiang, BBY, Roberts, AM, Kashem, AM, Santamore, WP, Chien, S, Gray, L & Dowling, R 2000, 'Chemoreflexes: An experimental study', Archives of Surgery, vol. 135, no. 5, pp. 577-581. https://doi.org/10.1001/archsurg.135.5.577

Chemoreflexes : An experimental study. / Chiang, Benjamin B.Y.; Roberts, Andrew M.; Kashem, Abul M.; Santamore, William P.; Chien, Sufan; Gray, Laman; Dowling, Robert.

In: Archives of Surgery, Vol. 135, No. 5, 05.2000, p. 577-581.

Research output: Contribution to journalArticle

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T2 - An experimental study

AU - Chiang, Benjamin B.Y.

AU - Roberts, Andrew M.

AU - Kashem, Abul M.

AU - Santamore, William P.

AU - Chien, Sufan

AU - Gray, Laman

AU - Dowling, Robert

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AB - Hypothesis: Transmyocardial laser revascularization (TMLR) will not denervate the heart, because it does not destroy all of the afferents. This study was designed to determine if stimulation of cardiac sympathetic and vagal afferents from an area of the left ventricle treated with TMLR could evoke reflex effects, and thus whether TMLR would denervate the heart. Methods: The effect of TMLR on reflexes evoked by chemically stimulating cardiac afferents was examined in 9 dogs. Bradykinin and capsaicin were applied topically or injected into the left anterior descending coronary artery before and after TMLR and after bilateral vagotomy and sympathectomy. Aortic (AoP) and left ventricular pressures (LVP) and electrocardiography were monitored. The first derivatives of LVP (dP/dt) were calculated. Results: Topical bradykinin elicited variable hemodynamic responses. Topical capsaicin evoked pressor responses, increasing mean (± SEM) AoP (105±9 to 115±9 mm Hg; P<.001) and positive dP/dt (+dP/dt) (1032±81 to 1159±10 mm Hg/s; P<.01) before TMLR. Intracoronary capsaicin evoked a depressor response before TMLR. Pressor responses remained intact after TMLR with increases in mean AoP and +dP/dt (115±6 to 128±5 mm Hg and 1039±98 to 1136±100 mm Hg/s, respectively; P<.01). Depressor responses also remained intact after TMLR (91±10 vs 101±11 mm Hg [P<.02], and 865±104 vs 931±104 mm Hg/s [P<.05], respectively). Hemodynamic responses were diminished after bilateral vagotomy and abolished after bilateral sympathectomy. Conclusion: Since activation of cardiac afferent nerves and reflex responses remained intact after TMLR, but changed after vagotomy or sympathectomy, TMLR does not denervate the heart sufficiently to be the cause of improved angina after TMLR.

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Chiang BBY, Roberts AM, Kashem AM, Santamore WP, Chien S, Gray L et al. Chemoreflexes: An experimental study. Archives of Surgery. 2000 May;135(5):577-581. https://doi.org/10.1001/archsurg.135.5.577