Chemotaxis to the quorum-sensing signal AI-2 requires the Tsr chemoreceptor and the periplasmic LsrB AI-2-binding protein

Manjunath Hegde, Derek L. Englert, Shanna Schrock, William B. Cohn, Christian Vogt, Thomas K. Wood, Michael D. Manson, Arul Jayaraman

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

AI-2 is an autoinducer made by many bacteria. LsrB binds AI-2 in the periplasm, and Tsr is the L-serine chemoreceptor. We show that AI-2 strongly attracts Escherichia coli. Both LsrB and Tsr are necessary for sensing AI-2, but AI-2 uptake is not, suggesting that LsrB and Tsr interact directly in the periplasm.

Original languageEnglish (US)
Pages (from-to)768-773
Number of pages6
JournalJournal of bacteriology
Volume193
Issue number3
DOIs
StatePublished - Feb 2011

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

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