Child assessment of dextromethorphan, diphenhydramine, and placebo for nocturnal cough due to upper respiratory infection

Katharine E. Yoder, Michele L. Shaffer, Susan J. La Tournous, Ian M. Paul

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

This study sought to investigate the efficacy of dextromethorphan (DM), diphenhydramine (DPH), and placebo (PL) for symptoms attributed to upper respiratory infections as determined by children, and to evaluate the concordance of perception of nocturnal symptoms between children and parents. A total of 37 children age 6 to 18 years of age were randomized in a double-masked fashion to receive a single bedtime dose of DM, DPH, or PL. Children found no significant difference in the effect of DM, DPH, or PL for any study outcome, and responses by parents and children were significantly correlated.

Original languageEnglish (US)
Pages (from-to)633-640
Number of pages8
JournalClinical Pediatrics
Volume45
Issue number7
DOIs
StatePublished - Sep 2006

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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