Abstract
Gut and oral microbiota perturbations have been observed in obese adults and adolescents; less is known about their influence on weight gain in young children. Here we analyzed the gut and oral microbiota of 226 two-year-olds with 16S rRNA gene sequencing. Weight and length were measured at seven time points and used to identify children with rapid infant weight gain (a strong risk factor for childhood obesity), and to derive growth curves with innovative Functional Data Analysis (FDA) techniques. We showed that growth curves were associated negatively with diversity, and positively with the Firmicutes-to-Bacteroidetes ratio, of the oral microbiota. We also demonstrated an association between the gut microbiota and child growth, even after controlling for the effect of diet on the microbiota. Lastly, we identified several bacterial genera that were associated with child growth patterns. These results suggest that by the age of two, the oral microbiota of children with rapid infant weight gain may have already begun to establish patterns often seen in obese adults. They also suggest that the gut microbiota at age two, while strongly influenced by diet, does not harbor obesity signatures many researchers identified in later life stages.
| Original language | English (US) |
|---|---|
| Article number | 14030 |
| Journal | Scientific reports |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 1 2018 |
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Child Weight Gain Trajectories Linked To Oral Microbiota Composition. / Craig, Sarah; Blankenberg, Daniel; Parodi, Alice Carla Luisa; Paul, Ian; Birch, Leann L.; Williams, Jennifer Savage; Marini, Michele E.; Stokes, Jennifer L.; Nekrutenko, Anton; Reimherr, Matthew Logan; Chiaromonte, Francesca; Makova, Kateryna Dmytrivna.
In: Scientific reports, Vol. 8, No. 1, 14030, 01.12.2018.Research output: Contribution to journal › Article
TY - JOUR
T1 - Child Weight Gain Trajectories Linked To Oral Microbiota Composition
AU - Craig, Sarah
AU - Blankenberg, Daniel
AU - Parodi, Alice Carla Luisa
AU - Paul, Ian
AU - Birch, Leann L.
AU - Williams, Jennifer Savage
AU - Marini, Michele E.
AU - Stokes, Jennifer L.
AU - Nekrutenko, Anton
AU - Reimherr, Matthew Logan
AU - Chiaromonte, Francesca
AU - Makova, Kateryna Dmytrivna
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Gut and oral microbiota perturbations have been observed in obese adults and adolescents; less is known about their influence on weight gain in young children. Here we analyzed the gut and oral microbiota of 226 two-year-olds with 16S rRNA gene sequencing. Weight and length were measured at seven time points and used to identify children with rapid infant weight gain (a strong risk factor for childhood obesity), and to derive growth curves with innovative Functional Data Analysis (FDA) techniques. We showed that growth curves were associated negatively with diversity, and positively with the Firmicutes-to-Bacteroidetes ratio, of the oral microbiota. We also demonstrated an association between the gut microbiota and child growth, even after controlling for the effect of diet on the microbiota. Lastly, we identified several bacterial genera that were associated with child growth patterns. These results suggest that by the age of two, the oral microbiota of children with rapid infant weight gain may have already begun to establish patterns often seen in obese adults. They also suggest that the gut microbiota at age two, while strongly influenced by diet, does not harbor obesity signatures many researchers identified in later life stages.
AB - Gut and oral microbiota perturbations have been observed in obese adults and adolescents; less is known about their influence on weight gain in young children. Here we analyzed the gut and oral microbiota of 226 two-year-olds with 16S rRNA gene sequencing. Weight and length were measured at seven time points and used to identify children with rapid infant weight gain (a strong risk factor for childhood obesity), and to derive growth curves with innovative Functional Data Analysis (FDA) techniques. We showed that growth curves were associated negatively with diversity, and positively with the Firmicutes-to-Bacteroidetes ratio, of the oral microbiota. We also demonstrated an association between the gut microbiota and child growth, even after controlling for the effect of diet on the microbiota. Lastly, we identified several bacterial genera that were associated with child growth patterns. These results suggest that by the age of two, the oral microbiota of children with rapid infant weight gain may have already begun to establish patterns often seen in obese adults. They also suggest that the gut microbiota at age two, while strongly influenced by diet, does not harbor obesity signatures many researchers identified in later life stages.
UR - http://www.scopus.com/inward/record.url?scp=85053527252&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053527252&partnerID=8YFLogxK
U2 - 10.1038/s41598-018-31866-9
DO - 10.1038/s41598-018-31866-9
M3 - Article
C2 - 30232389
AN - SCOPUS:85053527252
VL - 8
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 14030
ER -