@article{35491c39c7924006885cde37724a3895,
title = "Child Weight Gain Trajectories Linked To Oral Microbiota Composition",
abstract = "Gut and oral microbiota perturbations have been observed in obese adults and adolescents; less is known about their influence on weight gain in young children. Here we analyzed the gut and oral microbiota of 226 two-year-olds with 16S rRNA gene sequencing. Weight and length were measured at seven time points and used to identify children with rapid infant weight gain (a strong risk factor for childhood obesity), and to derive growth curves with innovative Functional Data Analysis (FDA) techniques. We showed that growth curves were associated negatively with diversity, and positively with the Firmicutes-to-Bacteroidetes ratio, of the oral microbiota. We also demonstrated an association between the gut microbiota and child growth, even after controlling for the effect of diet on the microbiota. Lastly, we identified several bacterial genera that were associated with child growth patterns. These results suggest that by the age of two, the oral microbiota of children with rapid infant weight gain may have already begun to establish patterns often seen in obese adults. They also suggest that the gut microbiota at age two, while strongly influenced by diet, does not harbor obesity signatures many researchers identified in later life stages.",
author = "Craig, {Sarah J.C.} and Daniel Blankenberg and Parodi, {Alice Carla Luisa} and Paul, {Ian M.} and Birch, {Leann L.} and Savage, {Jennifer S.} and Marini, {Michele E.} and Stokes, {Jennifer L.} and Anton Nekrutenko and Matthew Reimherr and Francesca Chiaromonte and Makova, {Kateryna D.}",
note = "Funding Information: We are grateful to all INSIGHT families and nurses for their participation in this study. We would like to thank B. Higgins, A. Shelly, P. Carper, J. Beiler, N. Verdiglione, L. Hess, and the Penn State Genomics Core Facility, University Park, PA for their assistance. This project is supported by grants R01DK088244 and R01DK99364 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This project is also supported by the funds from the Eberly College of Sciences at PSU, by the Penn State Institute of Cyberscience, by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health (through Grant UL1TR000127). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Additionally, this project is funded, in part, under a grant with the Pennsylvania Department of Health using Tobacco Settlement and CURE funds. The Department specifically disclaims responsibility for any analyses, interpretations, or conclusions. Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41598-018-31866-9",
language = "English (US)",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}