Childhood high-frequency EEG activity during sleep is associated with incident insomnia symptoms in adolescence

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Insomnia has been associated in cross-sectional studies with increased beta (15–35 Hz) electroencephalogram (EEG) power during nonrapid eye movement (NREM) sleep, an index of cortical hyperarousal. However, it is unknown whether this cortical hyperarousal is present before individuals with insomnia develop the disorder. To fill this gap, we examined the association of childhood sleep high-frequency EEG activity with incident insomnia symptoms (i.e., absence of insomnia symptoms in childhood but presence in adolescence). Methods: We studied a case–control subsample of 45 children (6–11 years) from the Penn State Child Cohort, a population-based random sample of 421 children, who were followed up after 8 years as adolescents (13–20 years). We examined low-beta (15–25 Hz) and high-beta (25–35 Hz) relative power at central EEG derivations during NREM sleep and, in secondary analyses, during sleep onset latency, sleep onset, and REM sleep. Incident insomnia symptoms were defined as the absence of parent-reported difficulty falling and/or staying asleep during childhood and a self-report of these insomnia symptoms during adolescence. Results: Childhood high-beta power during NREM sleep was significantly increased in children who developed insomnia symptoms in adolescence (n = 25) as compared to normal sleeping controls (n = 20; p =.03). Multivariable-adjusted logistic regression models showed that increased childhood high-beta EEG power during NREM sleep was associated with a threefold increased odds (95% CI = 1.12–7.98) of incident insomnia symptoms in adolescence. No other significant relationships were observed for other sleep/wake states or EEG frequency bands. Conclusions: Increased childhood high-frequency EEG power during NREM sleep is associated with incident insomnia symptoms in adolescence. This study indicates that cortical hyperarousal during sleep may be a premorbid neurophysiological sign of insomnia, which may mediate the increased risk of psychiatric disorders associated with insomnia.

Original languageEnglish (US)
Pages (from-to)742-751
Number of pages10
JournalJournal of Child Psychology and Psychiatry and Allied Disciplines
Volume60
Issue number7
DOIs
StatePublished - Jul 1 2019

Fingerprint

Sleep Initiation and Maintenance Disorders
Electroencephalography
Sleep
Eye Movements
Accidental Falls
Logistic Models
REM Sleep
Self Report
Psychiatry
Cross-Sectional Studies
Power (Psychology)

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

@article{d9640456f79b463d86195b71c5903bd6,
title = "Childhood high-frequency EEG activity during sleep is associated with incident insomnia symptoms in adolescence",
abstract = "Background: Insomnia has been associated in cross-sectional studies with increased beta (15–35 Hz) electroencephalogram (EEG) power during nonrapid eye movement (NREM) sleep, an index of cortical hyperarousal. However, it is unknown whether this cortical hyperarousal is present before individuals with insomnia develop the disorder. To fill this gap, we examined the association of childhood sleep high-frequency EEG activity with incident insomnia symptoms (i.e., absence of insomnia symptoms in childhood but presence in adolescence). Methods: We studied a case–control subsample of 45 children (6–11 years) from the Penn State Child Cohort, a population-based random sample of 421 children, who were followed up after 8 years as adolescents (13–20 years). We examined low-beta (15–25 Hz) and high-beta (25–35 Hz) relative power at central EEG derivations during NREM sleep and, in secondary analyses, during sleep onset latency, sleep onset, and REM sleep. Incident insomnia symptoms were defined as the absence of parent-reported difficulty falling and/or staying asleep during childhood and a self-report of these insomnia symptoms during adolescence. Results: Childhood high-beta power during NREM sleep was significantly increased in children who developed insomnia symptoms in adolescence (n = 25) as compared to normal sleeping controls (n = 20; p =.03). Multivariable-adjusted logistic regression models showed that increased childhood high-beta EEG power during NREM sleep was associated with a threefold increased odds (95{\%} CI = 1.12–7.98) of incident insomnia symptoms in adolescence. No other significant relationships were observed for other sleep/wake states or EEG frequency bands. Conclusions: Increased childhood high-frequency EEG power during NREM sleep is associated with incident insomnia symptoms in adolescence. This study indicates that cortical hyperarousal during sleep may be a premorbid neurophysiological sign of insomnia, which may mediate the increased risk of psychiatric disorders associated with insomnia.",
author = "Julio Fernandez-Mendoza and Yun Li and Jidong Fang and Susan Calhoun and Alexandros Vgontzas and Duanping Liao and Edward Bixler",
year = "2019",
month = "7",
day = "1",
doi = "10.1111/jcpp.12945",
language = "English (US)",
volume = "60",
pages = "742--751",
journal = "Journal of Child Psychology and Psychiatry and Allied Disciplines",
issn = "0021-9630",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Childhood high-frequency EEG activity during sleep is associated with incident insomnia symptoms in adolescence

AU - Fernandez-Mendoza, Julio

AU - Li, Yun

AU - Fang, Jidong

AU - Calhoun, Susan

AU - Vgontzas, Alexandros

AU - Liao, Duanping

AU - Bixler, Edward

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background: Insomnia has been associated in cross-sectional studies with increased beta (15–35 Hz) electroencephalogram (EEG) power during nonrapid eye movement (NREM) sleep, an index of cortical hyperarousal. However, it is unknown whether this cortical hyperarousal is present before individuals with insomnia develop the disorder. To fill this gap, we examined the association of childhood sleep high-frequency EEG activity with incident insomnia symptoms (i.e., absence of insomnia symptoms in childhood but presence in adolescence). Methods: We studied a case–control subsample of 45 children (6–11 years) from the Penn State Child Cohort, a population-based random sample of 421 children, who were followed up after 8 years as adolescents (13–20 years). We examined low-beta (15–25 Hz) and high-beta (25–35 Hz) relative power at central EEG derivations during NREM sleep and, in secondary analyses, during sleep onset latency, sleep onset, and REM sleep. Incident insomnia symptoms were defined as the absence of parent-reported difficulty falling and/or staying asleep during childhood and a self-report of these insomnia symptoms during adolescence. Results: Childhood high-beta power during NREM sleep was significantly increased in children who developed insomnia symptoms in adolescence (n = 25) as compared to normal sleeping controls (n = 20; p =.03). Multivariable-adjusted logistic regression models showed that increased childhood high-beta EEG power during NREM sleep was associated with a threefold increased odds (95% CI = 1.12–7.98) of incident insomnia symptoms in adolescence. No other significant relationships were observed for other sleep/wake states or EEG frequency bands. Conclusions: Increased childhood high-frequency EEG power during NREM sleep is associated with incident insomnia symptoms in adolescence. This study indicates that cortical hyperarousal during sleep may be a premorbid neurophysiological sign of insomnia, which may mediate the increased risk of psychiatric disorders associated with insomnia.

AB - Background: Insomnia has been associated in cross-sectional studies with increased beta (15–35 Hz) electroencephalogram (EEG) power during nonrapid eye movement (NREM) sleep, an index of cortical hyperarousal. However, it is unknown whether this cortical hyperarousal is present before individuals with insomnia develop the disorder. To fill this gap, we examined the association of childhood sleep high-frequency EEG activity with incident insomnia symptoms (i.e., absence of insomnia symptoms in childhood but presence in adolescence). Methods: We studied a case–control subsample of 45 children (6–11 years) from the Penn State Child Cohort, a population-based random sample of 421 children, who were followed up after 8 years as adolescents (13–20 years). We examined low-beta (15–25 Hz) and high-beta (25–35 Hz) relative power at central EEG derivations during NREM sleep and, in secondary analyses, during sleep onset latency, sleep onset, and REM sleep. Incident insomnia symptoms were defined as the absence of parent-reported difficulty falling and/or staying asleep during childhood and a self-report of these insomnia symptoms during adolescence. Results: Childhood high-beta power during NREM sleep was significantly increased in children who developed insomnia symptoms in adolescence (n = 25) as compared to normal sleeping controls (n = 20; p =.03). Multivariable-adjusted logistic regression models showed that increased childhood high-beta EEG power during NREM sleep was associated with a threefold increased odds (95% CI = 1.12–7.98) of incident insomnia symptoms in adolescence. No other significant relationships were observed for other sleep/wake states or EEG frequency bands. Conclusions: Increased childhood high-frequency EEG power during NREM sleep is associated with incident insomnia symptoms in adolescence. This study indicates that cortical hyperarousal during sleep may be a premorbid neurophysiological sign of insomnia, which may mediate the increased risk of psychiatric disorders associated with insomnia.

UR - http://www.scopus.com/inward/record.url?scp=85050470177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050470177&partnerID=8YFLogxK

U2 - 10.1111/jcpp.12945

DO - 10.1111/jcpp.12945

M3 - Article

C2 - 29989664

AN - SCOPUS:85050470177

VL - 60

SP - 742

EP - 751

JO - Journal of Child Psychology and Psychiatry and Allied Disciplines

JF - Journal of Child Psychology and Psychiatry and Allied Disciplines

SN - 0021-9630

IS - 7

ER -