Chips and SNPs, bugs and thugs: A molecular sleuthing perspective

Thomas A. Cebula, Scott A. Jackson, Eric Wayne Brown, Biswendu Goswami, J. Eugene LeClerc

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Recent events both here and abroad have focused attention on the need for ensuring a safe and secure food supply. Although much has been written about the potential of particular select agents in bioterrorism, we must consider seriously the more mundane pathogens, especially those that have been implicated previously in foodborne outbreaks of human disease, as possible agents of bioterrorism. Given their evolutionary history, the enteric pathogens are more diverse than agents such as Bacillus anthracis, Francisella tularensis, or Yersinia pestis. This greater diversity, however, is a double-edged sword; although diversity affords the opportunity for unequivocal identification of an organism without the need for whole-genome sequencing, the same diversity can confound definitive forensic identification if boundaries are not well defined. Here, we discuss molecular approaches used for the identification of Salmonella enterica, Escherichia coli, and Shigella spp. and viral pathogens and discuss the utility of these approaches to the field of microbial molecular forensics.

Original languageEnglish (US)
Pages (from-to)1271-1284
Number of pages14
JournalJournal of Food Protection
Volume68
Issue number6
DOIs
StatePublished - Jan 1 2005

Fingerprint

Biological Warfare Agents
bioterrorism
Single Nucleotide Polymorphism
Francisella tularensis
Yersinia pestis
Bacillus anthracis
Shigella
Salmonella enterica
Food Supply
pathogens
Disease Outbreaks
History
Genome
Escherichia coli
human diseases
history
genome
organisms
forensic sciences

All Science Journal Classification (ASJC) codes

  • Food Science
  • Microbiology

Cite this

Cebula, T. A., Jackson, S. A., Brown, E. W., Goswami, B., & Eugene LeClerc, J. (2005). Chips and SNPs, bugs and thugs: A molecular sleuthing perspective. Journal of Food Protection, 68(6), 1271-1284. https://doi.org/10.4315/0362-028X-68.6.1271
Cebula, Thomas A. ; Jackson, Scott A. ; Brown, Eric Wayne ; Goswami, Biswendu ; Eugene LeClerc, J. / Chips and SNPs, bugs and thugs : A molecular sleuthing perspective. In: Journal of Food Protection. 2005 ; Vol. 68, No. 6. pp. 1271-1284.
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Cebula, TA, Jackson, SA, Brown, EW, Goswami, B & Eugene LeClerc, J 2005, 'Chips and SNPs, bugs and thugs: A molecular sleuthing perspective', Journal of Food Protection, vol. 68, no. 6, pp. 1271-1284. https://doi.org/10.4315/0362-028X-68.6.1271

Chips and SNPs, bugs and thugs : A molecular sleuthing perspective. / Cebula, Thomas A.; Jackson, Scott A.; Brown, Eric Wayne; Goswami, Biswendu; Eugene LeClerc, J.

In: Journal of Food Protection, Vol. 68, No. 6, 01.01.2005, p. 1271-1284.

Research output: Contribution to journalArticle

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Cebula TA, Jackson SA, Brown EW, Goswami B, Eugene LeClerc J. Chips and SNPs, bugs and thugs: A molecular sleuthing perspective. Journal of Food Protection. 2005 Jan 1;68(6):1271-1284. https://doi.org/10.4315/0362-028X-68.6.1271