Chiral elasticity of DNA

Hujun Shen, Patrick J. Hricko, Coray M. Colina, Scott Thomas Milner

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

DNA is a chiral semiflexible polymer, so its bending Hamiltonian may contain nonlinear terms coupling the curvature κ to the torsion τ, leading to an average torsion independent of curvature, with variance scaling as 1/κ2. We perform atomistic MD simulations of 31 base-pair DNA sequences with explicit solvent, in which thermal fluctuations cause the DNA to bend. We extract bending moduli by fitting to bending and torsional angle distributions. We find that chiral elasticity matters whenever DNA bends on a radius less than about 5 nm.

Original languageEnglish (US)
Pages (from-to)10090-10094
Number of pages5
JournalSoft Matter
Volume8
Issue number39
DOIs
StatePublished - Dec 1 2012

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Elasticity
deoxyribonucleic acid
elastic properties
Torsional stress
DNA
torsion
Hamiltonians
DNA sequences
curvature
Polymers
scaling
radii
causes
polymers
simulation
Hot Temperature

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Shen, H., Hricko, P. J., Colina, C. M., & Milner, S. T. (2012). Chiral elasticity of DNA. Soft Matter, 8(39), 10090-10094. https://doi.org/10.1039/c2sm26123e
Shen, Hujun ; Hricko, Patrick J. ; Colina, Coray M. ; Milner, Scott Thomas. / Chiral elasticity of DNA. In: Soft Matter. 2012 ; Vol. 8, No. 39. pp. 10090-10094.
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Shen, H, Hricko, PJ, Colina, CM & Milner, ST 2012, 'Chiral elasticity of DNA', Soft Matter, vol. 8, no. 39, pp. 10090-10094. https://doi.org/10.1039/c2sm26123e

Chiral elasticity of DNA. / Shen, Hujun; Hricko, Patrick J.; Colina, Coray M.; Milner, Scott Thomas.

In: Soft Matter, Vol. 8, No. 39, 01.12.2012, p. 10090-10094.

Research output: Contribution to journalArticle

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Shen H, Hricko PJ, Colina CM, Milner ST. Chiral elasticity of DNA. Soft Matter. 2012 Dec 1;8(39):10090-10094. https://doi.org/10.1039/c2sm26123e