Chlorinated Derivatives of Dibenzo-p-dioxin and Related Compounds for Use as Reference Compounds in Method Development and Environmental Toxicology

Elizabeth R. Barnhart, Donald George Jr Patterson, David L. Ashley, Vince Maggio, Cynthia C. Alley, Louis R. Alexander, J. Hugh MacBride

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Analytical reference standards are not readily available for many of the chlorinated aromatic compounds that have been Identified as environmental contaminants. We used sulfuryl chloride preparations to chlorinate aromatic compounds thereby obtaining the congeners needed as reference standards for gas chromatography/mass spectrometry analyses. We used commercially available vialed reagents and small vessels (reaction vials) for the production of milligram quantities of the toxicants. With biphenyl, dibenzofuran, and dibenzo-p-dioxin, the major products were polychloro derivatives of the respective starting material. With biphenylene and pyrene, polychloro-substltutlon products and addition products were also obtained. Polar constituents of the reaction mixtures were removed on silica gel, and the products were separated by high-performance liquid chromatography and identified by gas chromatography/mass spectrometry, nuclear magnetic resonance spectrometry, and Infrared spectrometry.

Original languageEnglish (US)
Pages (from-to)2248-2252
Number of pages5
JournalAnalytical chemistry
Volume59
Issue number18
DOIs
StatePublished - Jan 1 1987

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Aromatic compounds
Gas chromatography
Spectrometry
Mass spectrometry
Derivatives
Silica Gel
High performance liquid chromatography
Chlorides
Nuclear magnetic resonance
Impurities
Infrared radiation
dibenzo(1,4)dioxin
Ecotoxicology
dibenzofuran
pyrene
diphenyl

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

Cite this

Barnhart, E. R., Patterson, D. G. J., Ashley, D. L., Maggio, V., Alley, C. C., Alexander, L. R., & MacBride, J. H. (1987). Chlorinated Derivatives of Dibenzo-p-dioxin and Related Compounds for Use as Reference Compounds in Method Development and Environmental Toxicology. Analytical chemistry, 59(18), 2248-2252. https://doi.org/10.1021/ac00145a008
Barnhart, Elizabeth R. ; Patterson, Donald George Jr ; Ashley, David L. ; Maggio, Vince ; Alley, Cynthia C. ; Alexander, Louis R. ; MacBride, J. Hugh. / Chlorinated Derivatives of Dibenzo-p-dioxin and Related Compounds for Use as Reference Compounds in Method Development and Environmental Toxicology. In: Analytical chemistry. 1987 ; Vol. 59, No. 18. pp. 2248-2252.
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abstract = "Analytical reference standards are not readily available for many of the chlorinated aromatic compounds that have been Identified as environmental contaminants. We used sulfuryl chloride preparations to chlorinate aromatic compounds thereby obtaining the congeners needed as reference standards for gas chromatography/mass spectrometry analyses. We used commercially available vialed reagents and small vessels (reaction vials) for the production of milligram quantities of the toxicants. With biphenyl, dibenzofuran, and dibenzo-p-dioxin, the major products were polychloro derivatives of the respective starting material. With biphenylene and pyrene, polychloro-substltutlon products and addition products were also obtained. Polar constituents of the reaction mixtures were removed on silica gel, and the products were separated by high-performance liquid chromatography and identified by gas chromatography/mass spectrometry, nuclear magnetic resonance spectrometry, and Infrared spectrometry.",
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Barnhart, ER, Patterson, DGJ, Ashley, DL, Maggio, V, Alley, CC, Alexander, LR & MacBride, JH 1987, 'Chlorinated Derivatives of Dibenzo-p-dioxin and Related Compounds for Use as Reference Compounds in Method Development and Environmental Toxicology', Analytical chemistry, vol. 59, no. 18, pp. 2248-2252. https://doi.org/10.1021/ac00145a008

Chlorinated Derivatives of Dibenzo-p-dioxin and Related Compounds for Use as Reference Compounds in Method Development and Environmental Toxicology. / Barnhart, Elizabeth R.; Patterson, Donald George Jr; Ashley, David L.; Maggio, Vince; Alley, Cynthia C.; Alexander, Louis R.; MacBride, J. Hugh.

In: Analytical chemistry, Vol. 59, No. 18, 01.01.1987, p. 2248-2252.

Research output: Contribution to journalArticle

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AU - Barnhart, Elizabeth R.

AU - Patterson, Donald George Jr

AU - Ashley, David L.

AU - Maggio, Vince

AU - Alley, Cynthia C.

AU - Alexander, Louis R.

AU - MacBride, J. Hugh

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AB - Analytical reference standards are not readily available for many of the chlorinated aromatic compounds that have been Identified as environmental contaminants. We used sulfuryl chloride preparations to chlorinate aromatic compounds thereby obtaining the congeners needed as reference standards for gas chromatography/mass spectrometry analyses. We used commercially available vialed reagents and small vessels (reaction vials) for the production of milligram quantities of the toxicants. With biphenyl, dibenzofuran, and dibenzo-p-dioxin, the major products were polychloro derivatives of the respective starting material. With biphenylene and pyrene, polychloro-substltutlon products and addition products were also obtained. Polar constituents of the reaction mixtures were removed on silica gel, and the products were separated by high-performance liquid chromatography and identified by gas chromatography/mass spectrometry, nuclear magnetic resonance spectrometry, and Infrared spectrometry.

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