Cholesterol turnover and tissue distribution in the guinea pig in response to dietary cholesterol

M. H. Green, M. Crim, M. Traber, R. Ostwald

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Cholesterol turnover and tissue cholesterol distribution were studied in guinea pigs fed either a control diet or one containing 0.1% cholesterol. Dietary cholesterol caused a significant increase in the cholesterol concentration in liver, red blood cells and small intestine, but not in plasma. Most of the increase in total body cholesterol could be accounted for as an increase in liver esterified cholesterol content. Feeding the 0.1% cholesterol containing diet did not significantly change either the absorption of an oral dose of tracer cholesterol or the endogenous cholesterol synthesis rate. Steady state cholesterol input output rate and total traced mass of cholesterol were significantly greater, and mean transit time was significantly longer in the animals fed the cholesterol containing diet. These data suggest that the maintenance of cholesterol homeostasis in the nonhypercholesterolemic cholesterol fed guinea pig depends on liver accumulation of esterified cholesterol as well as on increased output of cholesterol.

Original languageEnglish (US)
Pages (from-to)515-528
Number of pages14
JournalJournal of Nutrition
Volume106
Issue number4
StatePublished - Dec 1 1976

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Dietary Cholesterol
Tissue Distribution
Guinea Pigs
Cholesterol
Diet
Liver

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Green, M. H., Crim, M., Traber, M., & Ostwald, R. (1976). Cholesterol turnover and tissue distribution in the guinea pig in response to dietary cholesterol. Journal of Nutrition, 106(4), 515-528.
Green, M. H. ; Crim, M. ; Traber, M. ; Ostwald, R. / Cholesterol turnover and tissue distribution in the guinea pig in response to dietary cholesterol. In: Journal of Nutrition. 1976 ; Vol. 106, No. 4. pp. 515-528.
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Green, MH, Crim, M, Traber, M & Ostwald, R 1976, 'Cholesterol turnover and tissue distribution in the guinea pig in response to dietary cholesterol', Journal of Nutrition, vol. 106, no. 4, pp. 515-528.

Cholesterol turnover and tissue distribution in the guinea pig in response to dietary cholesterol. / Green, M. H.; Crim, M.; Traber, M.; Ostwald, R.

In: Journal of Nutrition, Vol. 106, No. 4, 01.12.1976, p. 515-528.

Research output: Contribution to journalArticle

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