Cholinergic influence on the sensitivity of cough reflex in awake guinea-pigs

Yuxia Jia, K. Sekizawa, H. Sasaki

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

1. We studied the effects of an intraperitoneal (i.p.) administration of atropine on bronchomotor tone induced by carbachol aerosols in anaesthetized and ventilated guinea-pigs and on the sensitivity of cough reflex to capsaicin aerosols in awake guinea-pigs. 2. The intraperitoneal administration of atropine (10-8-10-6 M kg-1) reduced carbachol (8 mg ml-1; 1 min)-induced increases in pulmonary insufflation pressure and a complete inhibition was achieved at a dose of 10-6 M kg-1 in anaesthetized guinea-pigs. 3. In awake guinea pigs, capsaicin aerosols (10-5-10-3 M) caused dose-dependent increases in the number of coughs. Atropine (10-7-10-6 M kg-1 i.p.) shifted the dose-response curves to capsaicin to the right in a dose-dependent fashion. Carbachol aerosols, at the maximal concentration (2 mg ml-1) that did not cause bronchoconstriction, shifted them to the left compared with the control. 4. Atropine (10-6 M kg-1 i.p.) significantly increased the provocative concentration of capsaicin that caused five coughs (P < 0.01) and carbachol aerosols (2 mg ml-1) significantly decreased it (P < 0.01). 5. We conclude that cholinergically mediated airway tone regulates cough sensitivity in awake guinea pigs.

Original languageEnglish (US)
Pages (from-to)257-261
Number of pages5
JournalJournal of Autonomic Pharmacology
Volume18
Issue number5
DOIs
StatePublished - Nov 12 1998

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Pharmacology

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