TY - JOUR
T1 - Chorioamnionitis
T2 - Implications for the neonate
AU - Ericson, Jessica E.
AU - Laughon, Matthew M.
N1 - Funding Information:
Dr M.M. Laughon receives support from the U.S. government for his work in pediatric and neonatal clinical pharmacology (Government Contract HHSN267200700051C , PI: Benjamin under the Best Pharmaceuticals for Children Act) and from National Institute of Child Health and Human Development ( K23HD068497 ). Dr J.E. Ericson receives support from the National Institute of Child Health and Human Development of the National Institutes of Health under award number 5T32HD060558 .
Publisher Copyright:
© 2015 Elsevier Inc.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Chorioamnionitis (CA) is characterized by inflammation of the fetal membranes. The incidence increases with decreasing gestational age at birth. When suspected on clinical criteria, pathologic assessment of the placenta should be performed. Although the mechanisms are not entirely clear, CA predisposes to premature birth, neonatal sepsis, and intraventricular hemorrhage. Its role in respiratory distress syndrome, bronchopulmonary dysplasia, and neurodevelopmental impairment is mixed. Prevention and treatment are ill-defined; antibiotics for preterm premature rupture of membranes reduce the incidence and increase the length of time to delivery. Antibiotics are recommended for infants exposed to CA while laboratory studies are being performed.
AB - Chorioamnionitis (CA) is characterized by inflammation of the fetal membranes. The incidence increases with decreasing gestational age at birth. When suspected on clinical criteria, pathologic assessment of the placenta should be performed. Although the mechanisms are not entirely clear, CA predisposes to premature birth, neonatal sepsis, and intraventricular hemorrhage. Its role in respiratory distress syndrome, bronchopulmonary dysplasia, and neurodevelopmental impairment is mixed. Prevention and treatment are ill-defined; antibiotics for preterm premature rupture of membranes reduce the incidence and increase the length of time to delivery. Antibiotics are recommended for infants exposed to CA while laboratory studies are being performed.
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U2 - 10.1016/j.clp.2014.10.011
DO - 10.1016/j.clp.2014.10.011
M3 - Review article
C2 - 25678002
AN - SCOPUS:84922359420
VL - 42
SP - 155
EP - 165
JO - Clinics in Perinatology
JF - Clinics in Perinatology
SN - 0095-5108
IS - 1
ER -