Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene

Jiyue Zhu, Yuanjun Zhao, Shuwen Wang

Research output: Contribution to journalReview article

48 Citations (Scopus)

Abstract

Telomerase expression and telomere maintenance are critical for long-term cell proliferation and survival, and they play important roles in development, aging, and cancer. Cumulating evidence has indicated that regulation of the rate-limiting subunit of human telomerase reverse transcriptase gene (hTERT) is a complex process in normal cells and many cancer cells. In addition to a number of transcriptional activators and repressors, the chromatin environment and epigenetic status of the endogenous hTERT locus are also pivotal for its regulation in normal human somatic cells and in tumorigenesis.

Original languageEnglish (US)
Pages (from-to)22-32
Number of pages11
JournalProtein and Cell
Volume1
Issue number1
DOIs
StatePublished - Jan 1 2010

Fingerprint

Telomerase
Epigenomics
Chromatin
Genes
Cell proliferation
Aging of materials
Telomere
Cells
Neoplasms
Cell Survival
Carcinogenesis
Maintenance
Cell Proliferation
human TERT protein

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Drug Discovery
  • Cell Biology

Cite this

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Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene. / Zhu, Jiyue; Zhao, Yuanjun; Wang, Shuwen.

In: Protein and Cell, Vol. 1, No. 1, 01.01.2010, p. 22-32.

Research output: Contribution to journalReview article

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N2 - Telomerase expression and telomere maintenance are critical for long-term cell proliferation and survival, and they play important roles in development, aging, and cancer. Cumulating evidence has indicated that regulation of the rate-limiting subunit of human telomerase reverse transcriptase gene (hTERT) is a complex process in normal cells and many cancer cells. In addition to a number of transcriptional activators and repressors, the chromatin environment and epigenetic status of the endogenous hTERT locus are also pivotal for its regulation in normal human somatic cells and in tumorigenesis.

AB - Telomerase expression and telomere maintenance are critical for long-term cell proliferation and survival, and they play important roles in development, aging, and cancer. Cumulating evidence has indicated that regulation of the rate-limiting subunit of human telomerase reverse transcriptase gene (hTERT) is a complex process in normal cells and many cancer cells. In addition to a number of transcriptional activators and repressors, the chromatin environment and epigenetic status of the endogenous hTERT locus are also pivotal for its regulation in normal human somatic cells and in tumorigenesis.

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