Chromatin dynamics and genome organization in development and disease

Changwang Deng, Bhavita Patel, Xiumei Lin, Yangqiu Li, Suming Huang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Current technological advancements and genome-wide studies provide compelling evidence that dynamic chromatin interaction and three-dimensional genome organization in nuclei play an important role in regulating gene expression. This chapter highlights current technical advances in mapping interactions within the same chromosome (intrachromosomal) and between different chromosomes (interchromosomal), as well as outlines the roles of dynamic chromatin interactions in transcription regulation. We further explored the function of chromatin modulators, such as chromatin insulator binding protein CTCF, cohesin, SATB1, and transcription cofactors, in chromatin interactions and genome organization. Changes in higher-order organization of chromatin will alter global gene expression and promote genome rearrangements. Finally, we focused on the implications of these studies in cancer and development.

Original languageEnglish (US)
Title of host publicationEpigenetic Gene Expression and Regulation
PublisherElsevier Inc.
Pages95-115
Number of pages21
ISBN (Electronic)9780128004715
ISBN (Print)9780127999586
DOIs
Publication statusPublished - Jan 1 2015

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Deng, C., Patel, B., Lin, X., Li, Y., & Huang, S. (2015). Chromatin dynamics and genome organization in development and disease. In Epigenetic Gene Expression and Regulation (pp. 95-115). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-799958-6.00005-6