Chromosomal abnormalities associated with infertility

Joan M. Sulewski, Thao Phuong Dang, Karen A. Ferguson, Samuel P. Ward, Roger L. Ladda

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

From a population of 515 subfertile couples and 119 women with amenorrhea, 38 patients were karyotyped because of specific signs and symptoms suggestive of chromosomal abnormality. The indications for karyotyping included primary amenorrhea, secondary amenorrhea with gonadal failure before 35 years of age, stature of less than 147.5 cm, azoospermia with eunuchoidism, and personal or family history of more than 2 spontaneous abortions or more than 2 severely abnormal children. In addition, 19 patients from the same subfertile population were selected randomly for karyotyping to serve as controls. Using banding techniques, chromosomal abnormalities were found in 18 of the 38 specifically selected individuals, whereas no abnormality was found among those randomly selected. Three of the 18 patients had chromosomal abnormalities not previously described; their karyotypes were 46,XY/ 48,XY,+8,+21; 46,X,inv dup(Xq)(q26->q21); and 46,XY, t(9;20)(q22;q12).

Original languageEnglish (US)
Pages (from-to)469-475
Number of pages7
JournalObstetrics and gynecology
Volume55
Issue number4
StatePublished - Apr 1980

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Amenorrhea
Chromosome Aberrations
Infertility
Karyotyping
Eunuchism
Azoospermia
Spontaneous Abortion
Karyotype
Population
Signs and Symptoms

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Sulewski, J. M., Dang, T. P., Ferguson, K. A., Ward, S. P., & Ladda, R. L. (1980). Chromosomal abnormalities associated with infertility. Obstetrics and gynecology, 55(4), 469-475.
Sulewski, Joan M. ; Dang, Thao Phuong ; Ferguson, Karen A. ; Ward, Samuel P. ; Ladda, Roger L. / Chromosomal abnormalities associated with infertility. In: Obstetrics and gynecology. 1980 ; Vol. 55, No. 4. pp. 469-475.
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Sulewski, JM, Dang, TP, Ferguson, KA, Ward, SP & Ladda, RL 1980, 'Chromosomal abnormalities associated with infertility', Obstetrics and gynecology, vol. 55, no. 4, pp. 469-475.

Chromosomal abnormalities associated with infertility. / Sulewski, Joan M.; Dang, Thao Phuong; Ferguson, Karen A.; Ward, Samuel P.; Ladda, Roger L.

In: Obstetrics and gynecology, Vol. 55, No. 4, 04.1980, p. 469-475.

Research output: Contribution to journalArticle

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Sulewski JM, Dang TP, Ferguson KA, Ward SP, Ladda RL. Chromosomal abnormalities associated with infertility. Obstetrics and gynecology. 1980 Apr;55(4):469-475.