Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum

Jlanbing Mu, Junhul Duan, Kateryna Dmytrivna Makova, Deirdre A. Joy, Chuong Q. Huynh, Oralee H. Branch, Wen Hsiung Li, Xin Zhuan Su

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

The Malaria's Eve hypothesis, proposing a severe recent population bottleneck (about 3, 000-5, 000 years ago) of the human malaria parasite Plasmodium falciparum, has prompted a debate about the origin and evolution of the parasite1-6. The hypothesis implies that the parasite population is relatively homogeneous, favouring malaria control measures. Other studies, however, suggested an ancient origin and large effective population sizes5, 7-10. To test the hypothesis, we analysed single nucleotide polymorphisms (SNPs) from 204 genes on chromosome 3 of P. falciparum. We have identified 403 polymorphic sites, including 238 SNPs and 165 microsatellites, from five parasite clones, establishing chromosome-wide haplotypes and a dense map with one polymorphic marker per ∼2.3 kilobases. On the basis of synonymous SNPs and non-coding SNPs, we estimate the time to the most recent common ancestor to be ∼100, 000-180, 000 years, significantly older than the proposed bottleneck. Our estimated divergence time coincides approximately with the start of human population expansion11, and is consistent with a genetically complex organism able to evade host immunity and other antimalarial efforts.

Original languageEnglish (US)
Pages (from-to)323-326
Number of pages4
JournalNature
Volume418
Issue number6895
DOIs
StatePublished - Jul 18 2002

Fingerprint

Plasmodium falciparum
Single Nucleotide Polymorphism
Chromosomes
Parasites
Population
Malaria
Chromosomes, Human, Pair 3
Falciparum Malaria
Antimalarials
Microsatellite Repeats
Haplotypes
Immunity
Clone Cells
Genes

All Science Journal Classification (ASJC) codes

  • General

Cite this

Mu, J., Duan, J., Makova, K. D., Joy, D. A., Huynh, C. Q., Branch, O. H., ... Su, X. Z. (2002). Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum. Nature, 418(6895), 323-326. https://doi.org/10.1038/nature00836
Mu, Jlanbing ; Duan, Junhul ; Makova, Kateryna Dmytrivna ; Joy, Deirdre A. ; Huynh, Chuong Q. ; Branch, Oralee H. ; Li, Wen Hsiung ; Su, Xin Zhuan. / Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum. In: Nature. 2002 ; Vol. 418, No. 6895. pp. 323-326.
@article{6d907aff0acf4028b6844090ab3a8b45,
title = "Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum",
abstract = "The Malaria's Eve hypothesis, proposing a severe recent population bottleneck (about 3, 000-5, 000 years ago) of the human malaria parasite Plasmodium falciparum, has prompted a debate about the origin and evolution of the parasite1-6. The hypothesis implies that the parasite population is relatively homogeneous, favouring malaria control measures. Other studies, however, suggested an ancient origin and large effective population sizes5, 7-10. To test the hypothesis, we analysed single nucleotide polymorphisms (SNPs) from 204 genes on chromosome 3 of P. falciparum. We have identified 403 polymorphic sites, including 238 SNPs and 165 microsatellites, from five parasite clones, establishing chromosome-wide haplotypes and a dense map with one polymorphic marker per ∼2.3 kilobases. On the basis of synonymous SNPs and non-coding SNPs, we estimate the time to the most recent common ancestor to be ∼100, 000-180, 000 years, significantly older than the proposed bottleneck. Our estimated divergence time coincides approximately with the start of human population expansion11, and is consistent with a genetically complex organism able to evade host immunity and other antimalarial efforts.",
author = "Jlanbing Mu and Junhul Duan and Makova, {Kateryna Dmytrivna} and Joy, {Deirdre A.} and Huynh, {Chuong Q.} and Branch, {Oralee H.} and Li, {Wen Hsiung} and Su, {Xin Zhuan}",
year = "2002",
month = "7",
day = "18",
doi = "10.1038/nature00836",
language = "English (US)",
volume = "418",
pages = "323--326",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6895",

}

Mu, J, Duan, J, Makova, KD, Joy, DA, Huynh, CQ, Branch, OH, Li, WH & Su, XZ 2002, 'Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum', Nature, vol. 418, no. 6895, pp. 323-326. https://doi.org/10.1038/nature00836

Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum. / Mu, Jlanbing; Duan, Junhul; Makova, Kateryna Dmytrivna; Joy, Deirdre A.; Huynh, Chuong Q.; Branch, Oralee H.; Li, Wen Hsiung; Su, Xin Zhuan.

In: Nature, Vol. 418, No. 6895, 18.07.2002, p. 323-326.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum

AU - Mu, Jlanbing

AU - Duan, Junhul

AU - Makova, Kateryna Dmytrivna

AU - Joy, Deirdre A.

AU - Huynh, Chuong Q.

AU - Branch, Oralee H.

AU - Li, Wen Hsiung

AU - Su, Xin Zhuan

PY - 2002/7/18

Y1 - 2002/7/18

N2 - The Malaria's Eve hypothesis, proposing a severe recent population bottleneck (about 3, 000-5, 000 years ago) of the human malaria parasite Plasmodium falciparum, has prompted a debate about the origin and evolution of the parasite1-6. The hypothesis implies that the parasite population is relatively homogeneous, favouring malaria control measures. Other studies, however, suggested an ancient origin and large effective population sizes5, 7-10. To test the hypothesis, we analysed single nucleotide polymorphisms (SNPs) from 204 genes on chromosome 3 of P. falciparum. We have identified 403 polymorphic sites, including 238 SNPs and 165 microsatellites, from five parasite clones, establishing chromosome-wide haplotypes and a dense map with one polymorphic marker per ∼2.3 kilobases. On the basis of synonymous SNPs and non-coding SNPs, we estimate the time to the most recent common ancestor to be ∼100, 000-180, 000 years, significantly older than the proposed bottleneck. Our estimated divergence time coincides approximately with the start of human population expansion11, and is consistent with a genetically complex organism able to evade host immunity and other antimalarial efforts.

AB - The Malaria's Eve hypothesis, proposing a severe recent population bottleneck (about 3, 000-5, 000 years ago) of the human malaria parasite Plasmodium falciparum, has prompted a debate about the origin and evolution of the parasite1-6. The hypothesis implies that the parasite population is relatively homogeneous, favouring malaria control measures. Other studies, however, suggested an ancient origin and large effective population sizes5, 7-10. To test the hypothesis, we analysed single nucleotide polymorphisms (SNPs) from 204 genes on chromosome 3 of P. falciparum. We have identified 403 polymorphic sites, including 238 SNPs and 165 microsatellites, from five parasite clones, establishing chromosome-wide haplotypes and a dense map with one polymorphic marker per ∼2.3 kilobases. On the basis of synonymous SNPs and non-coding SNPs, we estimate the time to the most recent common ancestor to be ∼100, 000-180, 000 years, significantly older than the proposed bottleneck. Our estimated divergence time coincides approximately with the start of human population expansion11, and is consistent with a genetically complex organism able to evade host immunity and other antimalarial efforts.

UR - http://www.scopus.com/inward/record.url?scp=0037130233&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037130233&partnerID=8YFLogxK

U2 - 10.1038/nature00836

DO - 10.1038/nature00836

M3 - Article

VL - 418

SP - 323

EP - 326

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6895

ER -

Mu J, Duan J, Makova KD, Joy DA, Huynh CQ, Branch OH et al. Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum. Nature. 2002 Jul 18;418(6895):323-326. https://doi.org/10.1038/nature00836