Chronic alcohol abuse and the acute sedative and neurophysiologic effects of midazolam

Lance O. Bauer, Jeffrey B. Gross, Roger E. Meyer, David J. Greenblatt

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The aim of the present investigation was to examine benzodiazepine sensitivity in abstinent alcoholics. For this purpose, two escalating doses of the benzodiazepine midazolam were IV administered to nine alcohol-dependent patients after 2-3 weeks of abstinence and 12 healthy, non-alcoholic volunteers. A variety of dependent measures were examined, including the power spectrum of the resting electroencephalogram (EEG) and evoked EEG responses, saccadic eye movements, self-reported sedation, and vigilance task performance. Analyses revealed a significant association between plasma midazolam levels and changes in EEG beta power, pattern shift visual evoked potential amplitude, heart rate, and saccade amplitude and velocity. The patient and control groups differed significantly in the onset latencies of their saccadic eye movements, and marginally in EEG beta power, both before and after midazolam. However, no differences were detected between the groups in the dose of midazolam required to produce sedation or in midazolam's neurophysiological effects.

Original languageEnglish (US)
Pages (from-to)293-299
Number of pages7
JournalPsychopharmacology
Volume133
Issue number3
DOIs
StatePublished - Oct 28 1997

All Science Journal Classification (ASJC) codes

  • Pharmacology

Fingerprint Dive into the research topics of 'Chronic alcohol abuse and the acute sedative and neurophysiologic effects of midazolam'. Together they form a unique fingerprint.

Cite this