Chronic alcohol alters rewarded behaviors and striatal plasticity

Lauren DePoy, Rachel Daut, Tara Wright, Marguerite Camp, Nicole Crowley, Bianca Noronha, David Lovinger, Andrew Holmes

Research output: Contribution to journalArticle

25 Scopus citations


Chronic intermittent ethanol (CIE) alters neural functions and behaviors mediated by the dorsolateral striatum (DLS) and prefrontal cortex. Here, we examined the effects of prolonged (16-bout) CIE on DLS plasticity and DLS-mediated behaviors. Ex vivo electrophysiological recordings revealed loss in efficacy of DLS synaptically induced activation and absent long-term depression after CIE. CIE increased two-bottle choice drinking and impaired Pavlovian-to-instrumental transfer but not discriminated approach. These data suggest prolonged CIE impaired DLS plasticity, to produce associated changes in drinking and cue-controlled reward-seeking. Given recent evidence that less-prolonged CIE can promote certain dorsal striatal-mediated behaviors, CIE may drive chronicity-dependent adaptations in corticostriatal systems regulating behavior.

Original languageEnglish (US)
Pages (from-to)345-348
Number of pages4
JournalAddiction Biology
Issue number2
StatePublished - Mar 1 2015

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology
  • Psychiatry and Mental health

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    DePoy, L., Daut, R., Wright, T., Camp, M., Crowley, N., Noronha, B., Lovinger, D., & Holmes, A. (2015). Chronic alcohol alters rewarded behaviors and striatal plasticity. Addiction Biology, 20(2), 345-348.