Chronic inflammatory demyelinating polyradiculoneuropathy in children: II. Long-term follow-up, with comparison to adults

Zachary Simmons, John J. Wald, James W. Albers

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

We previously reviewed the presentation, initial clinical course, and electrodiagnostic features of children with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We now report the long-term follow-up of 12 children with idiopathic CIDP, and compare these to 62 adults with idiopathic CIDP. Children often had more rapidly fluctuating courses than adults. A relapsing course was significantly more common in children than in adults. The recovery of children from each episode of deterioration was usually excellent, and better, on average, than in adults. Ventilatory support was never required for children with slowly evolving illness; only 2 children with a precipitous onset clinically resembling Guillain-Barre syndrome required ventilatory support. Prednisone, plasma exchange, and intravenous immunoglobulin (IVIg) usually were effective in children. Multiple courses of IVIg could be given with continued efficacy. Treatment often could be discontinued in children with relapsing courses. The prognosis for children was excellent. Adults demonstrated a good, but more variable, outcome.

Original languageEnglish (US)
Pages (from-to)1569-1575
Number of pages7
JournalMuscle and Nerve
Volume20
Issue number12
DOIs
StatePublished - Dec 12 1997

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Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Intravenous Immunoglobulins
Plasma Exchange
Guillain-Barre Syndrome
Prednisone

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

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Chronic inflammatory demyelinating polyradiculoneuropathy in children : II. Long-term follow-up, with comparison to adults. / Simmons, Zachary; Wald, John J.; Albers, James W.

In: Muscle and Nerve, Vol. 20, No. 12, 12.12.1997, p. 1569-1575.

Research output: Contribution to journalArticle

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