Chronic Osteomyelitis caused by Staphylococcus Aureus: Controlled Clinical Trial of Nafcillin Therapy and Nafcillin-Rifampin Therapy

Carl W. Norden, Richard Bryant, Darwin Palmer, John Z. Montgomerie, Joseph Wheat, Steve M. Jones, Charles B. Bird, Alan I. Hartstein, Robert C. Moellering, Adolf W. Karchmer, Robert Aber, Robert Greer, Monto Ho, Allen J. Weinstein, John P. Phair, Merle A. Sande, Gerald L. Mandell, Joshua Fierer, Dale Daniel, William A. CraigJon T. Mader, James A. Reinarz, Chronic Staphylococcal Osteomyelitis Study Group The Chronic Staphylococcal Osteomyelitis Study Group

Research output: Contribution to journalArticle

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Abstract

A controlled trial of treatment of chronic osteomyelitis caused by Staphylococcus aureus compared nafcillin alone with nafcillin plus rifampin for a six-week period. Treatment was well tolerated, the only adverse effect being mild neutropenia in four of 18 patients; no toxicity was observed from rifampin. Eight of ten patients in the combined treatment group had a favorable clinical response (with follow-up of two to four years) as compared to four of eight in the nafcillin group (P =.2). Despite the failure to show a statistically significant advantage of rifampin plus nafcillin, we conclude that the combination, along with appropriate surgery, should be chronic staphylococcal osteomyelitis.

Original languageEnglish (US)
Pages (from-to)947-951
Number of pages5
JournalSouthern Medical Journal
Volume79
Issue number8
DOIs
StatePublished - Jan 1 1986

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Nafcillin
Controlled Clinical Trials
Osteomyelitis
Rifampin
Staphylococcus aureus
Therapeutics
Neutropenia

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Norden, C. W., Bryant, R., Palmer, D., Montgomerie, J. Z., Wheat, J., Jones, S. M., ... The Chronic Staphylococcal Osteomyelitis Study Group, C. S. O. S. G. (1986). Chronic Osteomyelitis caused by Staphylococcus Aureus: Controlled Clinical Trial of Nafcillin Therapy and Nafcillin-Rifampin Therapy. Southern Medical Journal, 79(8), 947-951. https://doi.org/10.1097/00007611-198608000-00008
Norden, Carl W. ; Bryant, Richard ; Palmer, Darwin ; Montgomerie, John Z. ; Wheat, Joseph ; Jones, Steve M. ; Bird, Charles B. ; Hartstein, Alan I. ; Moellering, Robert C. ; Karchmer, Adolf W. ; Aber, Robert ; Greer, Robert ; Ho, Monto ; Weinstein, Allen J. ; Phair, John P. ; Sande, Merle A. ; Mandell, Gerald L. ; Fierer, Joshua ; Daniel, Dale ; Craig, William A. ; Mader, Jon T. ; Reinarz, James A. ; The Chronic Staphylococcal Osteomyelitis Study Group, Chronic Staphylococcal Osteomyelitis Study Group. / Chronic Osteomyelitis caused by Staphylococcus Aureus : Controlled Clinical Trial of Nafcillin Therapy and Nafcillin-Rifampin Therapy. In: Southern Medical Journal. 1986 ; Vol. 79, No. 8. pp. 947-951.
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abstract = "A controlled trial of treatment of chronic osteomyelitis caused by Staphylococcus aureus compared nafcillin alone with nafcillin plus rifampin for a six-week period. Treatment was well tolerated, the only adverse effect being mild neutropenia in four of 18 patients; no toxicity was observed from rifampin. Eight of ten patients in the combined treatment group had a favorable clinical response (with follow-up of two to four years) as compared to four of eight in the nafcillin group (P =.2). Despite the failure to show a statistically significant advantage of rifampin plus nafcillin, we conclude that the combination, along with appropriate surgery, should be chronic staphylococcal osteomyelitis.",
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Norden, CW, Bryant, R, Palmer, D, Montgomerie, JZ, Wheat, J, Jones, SM, Bird, CB, Hartstein, AI, Moellering, RC, Karchmer, AW, Aber, R, Greer, R, Ho, M, Weinstein, AJ, Phair, JP, Sande, MA, Mandell, GL, Fierer, J, Daniel, D, Craig, WA, Mader, JT, Reinarz, JA & The Chronic Staphylococcal Osteomyelitis Study Group, CSOSG 1986, 'Chronic Osteomyelitis caused by Staphylococcus Aureus: Controlled Clinical Trial of Nafcillin Therapy and Nafcillin-Rifampin Therapy', Southern Medical Journal, vol. 79, no. 8, pp. 947-951. https://doi.org/10.1097/00007611-198608000-00008

Chronic Osteomyelitis caused by Staphylococcus Aureus : Controlled Clinical Trial of Nafcillin Therapy and Nafcillin-Rifampin Therapy. / Norden, Carl W.; Bryant, Richard; Palmer, Darwin; Montgomerie, John Z.; Wheat, Joseph; Jones, Steve M.; Bird, Charles B.; Hartstein, Alan I.; Moellering, Robert C.; Karchmer, Adolf W.; Aber, Robert; Greer, Robert; Ho, Monto; Weinstein, Allen J.; Phair, John P.; Sande, Merle A.; Mandell, Gerald L.; Fierer, Joshua; Daniel, Dale; Craig, William A.; Mader, Jon T.; Reinarz, James A.; The Chronic Staphylococcal Osteomyelitis Study Group, Chronic Staphylococcal Osteomyelitis Study Group.

In: Southern Medical Journal, Vol. 79, No. 8, 01.01.1986, p. 947-951.

Research output: Contribution to journalArticle

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AU - Weinstein, Allen J.

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AU - Mandell, Gerald L.

AU - Fierer, Joshua

AU - Daniel, Dale

AU - Craig, William A.

AU - Mader, Jon T.

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AU - The Chronic Staphylococcal Osteomyelitis Study Group, Chronic Staphylococcal Osteomyelitis Study Group

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