Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patients

Peter H. Silverstone, Ren H. Wu, Tina O'Donnell, Michele Ulrich, Sheila Asghar, Christopher C. Hanstock

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Background. It has been proposed that lithium may be clinically effective due to its actions on the phosphoinositol second messenger system (PI-cycle). Studies have also suggested that untreated manic patients may have raised myo-inositol and phosphomonoester (PME) concentrations and also that unmedicated euthymic bipolar patients may have lowered PME concentrations. The objective of the present study was to test the hypothesis that chronic treatment with either lithium or sodium valproate in patients with bipolar mood disorder leads to a normalization in the activity of the PI-cycle. Methods. This study had two parts each with different MRS methodology. The first part compared healthy controls (n = 19) with euthymic bipolar patients who were taking either lithium (n = 16) or sodium valproate (n = 11) using both 1 H-MRS and 31 P-MRS. In the second part we examined a separate group of euthymic bipolar disorder patients taking sodium valproate (n = 9) and compared these with age and sex-matched healthy controls (n = 11) using 1 H-MRS. Results. Both studies showed that there were no differences in either myo-inositol or phosphomonoester (PME) concentrations between controls and patients taking either medication. Conclusions. These findings examine two key components of the PI-cycle in treated euthymic bipolar (myo-inositol and PME concentrations). The results from this study are coasistent with the suggestion that chronic treatment with either lithium or sodium valproate in bipolar patients may normalize PI-cycle functioning.

Original languageEnglish (US)
Pages (from-to)321-327
Number of pages7
JournalHuman Psychopharmacology
Volume17
Issue number7
DOIs
StatePublished - Oct 1 2002

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Activity Cycles
Valproic Acid
Lithium
Inositol
Bipolar Disorder
Therapeutics
Second Messenger Systems
Mood Disorders

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Silverstone, Peter H. ; Wu, Ren H. ; O'Donnell, Tina ; Ulrich, Michele ; Asghar, Sheila ; Hanstock, Christopher C. / Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patients. In: Human Psychopharmacology. 2002 ; Vol. 17, No. 7. pp. 321-327.
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Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patients. / Silverstone, Peter H.; Wu, Ren H.; O'Donnell, Tina; Ulrich, Michele; Asghar, Sheila; Hanstock, Christopher C.

In: Human Psychopharmacology, Vol. 17, No. 7, 01.10.2002, p. 321-327.

Research output: Contribution to journalArticle

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AU - Silverstone, Peter H.

AU - Wu, Ren H.

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AU - Ulrich, Michele

AU - Asghar, Sheila

AU - Hanstock, Christopher C.

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N2 - Background. It has been proposed that lithium may be clinically effective due to its actions on the phosphoinositol second messenger system (PI-cycle). Studies have also suggested that untreated manic patients may have raised myo-inositol and phosphomonoester (PME) concentrations and also that unmedicated euthymic bipolar patients may have lowered PME concentrations. The objective of the present study was to test the hypothesis that chronic treatment with either lithium or sodium valproate in patients with bipolar mood disorder leads to a normalization in the activity of the PI-cycle. Methods. This study had two parts each with different MRS methodology. The first part compared healthy controls (n = 19) with euthymic bipolar patients who were taking either lithium (n = 16) or sodium valproate (n = 11) using both 1 H-MRS and 31 P-MRS. In the second part we examined a separate group of euthymic bipolar disorder patients taking sodium valproate (n = 9) and compared these with age and sex-matched healthy controls (n = 11) using 1 H-MRS. Results. Both studies showed that there were no differences in either myo-inositol or phosphomonoester (PME) concentrations between controls and patients taking either medication. Conclusions. These findings examine two key components of the PI-cycle in treated euthymic bipolar (myo-inositol and PME concentrations). The results from this study are coasistent with the suggestion that chronic treatment with either lithium or sodium valproate in bipolar patients may normalize PI-cycle functioning.

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