Four patients suffering from chronic ulcerative (nongranulomatous) Jejunitis are described. Severe diarrhea with abdominal pain and fever, steatorrhea and hypoproteinemia due to enteric loss of plasma protein were the predominant clinical features. Peroral biopsies of the jejunal mucosa revealed villous atrophy in three patients but the characteristic pathologic abnormality in surgical biopsy specimens of the jejunum and in the small intestine examined at postmortem was the presence of multiple mucosal ulcers with adjacent areas of both atrophic and normal mucosa. Treatment with a gluten-free diet was ineffective, whereas corticosteroid therapy, although unpredictable in its effect, appeared to be of benefit to several patients. The differential diagnosis of this condition is discussed.
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