TY - JOUR
T1 - Chronic ulcerative (nongranulomatous) jejunitis
AU - Jeffries, Graham H.
AU - Steinberg, Herman
AU - Sleisenger, Marvin H.
N1 - Funding Information:
The patient’s first admission to the New York Hospital in July 1958 followed an episode of severe diarrhea. The only abnormalities on physical examination were slight abdominal distention, hyperactive bowel sounds and an enlarged liver palpable 1 cm. below the costal margin. He was afebrile. Laboratory tests included a normal hemoglobin and hematocrit, a white cell count of 8,000 per cu. mm. with a differential that included 28 per cent lymphocytes, 6 per cent eosinophils, 41 per cent mature polymorphonuclear cells and 22 per cent band forms. The urine * From the Division of Gastroenterology, Department of Medicine, Cornell University Medical College, New York, New York. Requests for reprints should be addressed to Dr. Graham H. Jeffries, New York Hospital, 525 East 68th Street, New York, New York 10021. Manuscript received December 22, 1966. t Recipient of Research Career Development Award, U. S. Public Health Service 5 K3-AM-14, 153.
PY - 1968/1
Y1 - 1968/1
N2 - Four patients suffering from chronic ulcerative (nongranulomatous) Jejunitis are described. Severe diarrhea with abdominal pain and fever, steatorrhea and hypoproteinemia due to enteric loss of plasma protein were the predominant clinical features. Peroral biopsies of the jejunal mucosa revealed villous atrophy in three patients but the characteristic pathologic abnormality in surgical biopsy specimens of the jejunum and in the small intestine examined at postmortem was the presence of multiple mucosal ulcers with adjacent areas of both atrophic and normal mucosa. Treatment with a gluten-free diet was ineffective, whereas corticosteroid therapy, although unpredictable in its effect, appeared to be of benefit to several patients. The differential diagnosis of this condition is discussed.
AB - Four patients suffering from chronic ulcerative (nongranulomatous) Jejunitis are described. Severe diarrhea with abdominal pain and fever, steatorrhea and hypoproteinemia due to enteric loss of plasma protein were the predominant clinical features. Peroral biopsies of the jejunal mucosa revealed villous atrophy in three patients but the characteristic pathologic abnormality in surgical biopsy specimens of the jejunum and in the small intestine examined at postmortem was the presence of multiple mucosal ulcers with adjacent areas of both atrophic and normal mucosa. Treatment with a gluten-free diet was ineffective, whereas corticosteroid therapy, although unpredictable in its effect, appeared to be of benefit to several patients. The differential diagnosis of this condition is discussed.
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U2 - 10.1016/0002-9343(68)90236-2
DO - 10.1016/0002-9343(68)90236-2
M3 - Article
C2 - 5635287
AN - SCOPUS:0014244535
VL - 44
SP - 47
EP - 59
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 1
ER -