Chronically decerebrate rats demonstrate satiation but not bait shyness

Harvey J. Grill, Ralph Norgren

Research output: Contribution to journalArticlepeer-review

311 Scopus citations

Abstract

Taste substances applied to the oral cavity result in either ingestion or rejection, each with a characteristic muscular response pattern. These responses are the same in decerebrate and intact rats; the caudal brainstem appears to be the neural substrate of ingestion and rejection responses. The experiment determined whether decerebrates can alter these discriminative responses as a function of food deprivation or toxicosis. Food-deprived decerebrate rats, like intact ones, ingested a taste substance they had rejected when sated. However, these same decerebrates, in contrast to controls, neither rejected nor decreased ingestive reactions to a novel taste after that taste had been repeatedly paired with lithium chloride-induced illness. Although the forebrain may be important for integrating ingestion, some aspects of this control seem to be represented in caudal brain areas.

Original languageEnglish (US)
Pages (from-to)267-269
Number of pages3
JournalScience
Volume201
Issue number4352
DOIs
StatePublished - Jan 1 1978

All Science Journal Classification (ASJC) codes

  • General

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