Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project

Delphine Praud, Matteo Rota, Claudio Pelucchi, Paola Bertuccio, Tiziana Rosso, Carlotta Galeone, Zuo Feng Zhang, Keitaro Matsuo, Hidemi Ito, Jinfu Hu, Kenneth C. Johnson, Guo Pei Yu, Domenico Palli, Monica Ferraroni, Joshua Muscat, Nuno Lunet, Bárbara Peleteiro, Reza Malekzadeh, Weimin Ye, Huan Song & 22 others David Zaridze, Dmitry Maximovitch, Nuria Aragonés, Gemma Castaño-Vinyals, Jesus Vioque, Eva M. Navarrete-Muñoz, Mohammadreza Pakseresht, Farhad Pourfarzi, Alicja Wolk, Nicola Orsini, Andrea Bellavia, Niclas Håkansson, Lina Mu, Roberta Pastorino, Robert C. Kurtz, Mohammad H. Derakhshan, Areti Lagiou, Pagona Lagiou, Paolo Boffetta, Stefania Boccia, Eva Negri, Carlo La Vecchia

Research output: Contribution to journalArticle

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Abstract

Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the 'Stomach cancer Pooling (StoP) Project', including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95% CI: 1.09-1.32) for ever, 1.12 (95% CI: 0.99-1.27) for former, and 1.25 (95% CI: 1.11-1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95% CI: 1.10-1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95% CI: 1.14-1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (P for trend<0.01) and became similar to that of never smokers 10 years after stopping. Risks were somewhat higher for cardia than noncardia gastric cancer. Risks were similar when considering only studies with information on Helicobacter pylori infection and comparing all cases to H. pylori+ controls only. This study provides the most precise estimate of the detrimental effect of cigarette smoking on the risk of gastric cancer on the basis of individual data, including the relationship with dose and duration, and the decrease in risk following stopping smoking.

LanguageEnglish (US)
Pages124-133
Number of pages10
JournalEuropean Journal of Cancer Prevention
Volume27
Issue number2
DOIs
StatePublished - Jan 1 2018

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Stomach Neoplasms
Smoking
Confidence Intervals
Odds Ratio
Tobacco Products
Helicobacter pylori
Cardia
Helicobacter Infections
Epidemiologic Studies

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Praud, D., Rota, M., Pelucchi, C., Bertuccio, P., Rosso, T., Galeone, C., ... La Vecchia, C. (2018). Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project. European Journal of Cancer Prevention, 27(2), 124-133. DOI: 10.1097/CEJ.0000000000000290
Praud, Delphine ; Rota, Matteo ; Pelucchi, Claudio ; Bertuccio, Paola ; Rosso, Tiziana ; Galeone, Carlotta ; Zhang, Zuo Feng ; Matsuo, Keitaro ; Ito, Hidemi ; Hu, Jinfu ; Johnson, Kenneth C. ; Yu, Guo Pei ; Palli, Domenico ; Ferraroni, Monica ; Muscat, Joshua ; Lunet, Nuno ; Peleteiro, Bárbara ; Malekzadeh, Reza ; Ye, Weimin ; Song, Huan ; Zaridze, David ; Maximovitch, Dmitry ; Aragonés, Nuria ; Castaño-Vinyals, Gemma ; Vioque, Jesus ; Navarrete-Muñoz, Eva M. ; Pakseresht, Mohammadreza ; Pourfarzi, Farhad ; Wolk, Alicja ; Orsini, Nicola ; Bellavia, Andrea ; Håkansson, Niclas ; Mu, Lina ; Pastorino, Roberta ; Kurtz, Robert C. ; Derakhshan, Mohammad H. ; Lagiou, Areti ; Lagiou, Pagona ; Boffetta, Paolo ; Boccia, Stefania ; Negri, Eva ; La Vecchia, Carlo. / Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project. In: European Journal of Cancer Prevention. 2018 ; Vol. 27, No. 2. pp. 124-133
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abstract = "Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the 'Stomach cancer Pooling (StoP) Project', including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95{\%} confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95{\%} CI: 1.09-1.32) for ever, 1.12 (95{\%} CI: 0.99-1.27) for former, and 1.25 (95{\%} CI: 1.11-1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95{\%} CI: 1.10-1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95{\%} CI: 1.14-1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (P for trend<0.01) and became similar to that of never smokers 10 years after stopping. Risks were somewhat higher for cardia than noncardia gastric cancer. Risks were similar when considering only studies with information on Helicobacter pylori infection and comparing all cases to H. pylori+ controls only. This study provides the most precise estimate of the detrimental effect of cigarette smoking on the risk of gastric cancer on the basis of individual data, including the relationship with dose and duration, and the decrease in risk following stopping smoking.",
author = "Delphine Praud and Matteo Rota and Claudio Pelucchi and Paola Bertuccio and Tiziana Rosso and Carlotta Galeone and Zhang, {Zuo Feng} and Keitaro Matsuo and Hidemi Ito and Jinfu Hu and Johnson, {Kenneth C.} and Yu, {Guo Pei} and Domenico Palli and Monica Ferraroni and Joshua Muscat and Nuno Lunet and B{\'a}rbara Peleteiro and Reza Malekzadeh and Weimin Ye and Huan Song and David Zaridze and Dmitry Maximovitch and Nuria Aragon{\'e}s and Gemma Casta{\~n}o-Vinyals and Jesus Vioque and Navarrete-Mu{\~n}oz, {Eva M.} and Mohammadreza Pakseresht and Farhad Pourfarzi and Alicja Wolk and Nicola Orsini and Andrea Bellavia and Niclas H{\aa}kansson and Lina Mu and Roberta Pastorino and Kurtz, {Robert C.} and Derakhshan, {Mohammad H.} and Areti Lagiou and Pagona Lagiou and Paolo Boffetta and Stefania Boccia and Eva Negri and {La Vecchia}, Carlo",
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Praud, D, Rota, M, Pelucchi, C, Bertuccio, P, Rosso, T, Galeone, C, Zhang, ZF, Matsuo, K, Ito, H, Hu, J, Johnson, KC, Yu, GP, Palli, D, Ferraroni, M, Muscat, J, Lunet, N, Peleteiro, B, Malekzadeh, R, Ye, W, Song, H, Zaridze, D, Maximovitch, D, Aragonés, N, Castaño-Vinyals, G, Vioque, J, Navarrete-Muñoz, EM, Pakseresht, M, Pourfarzi, F, Wolk, A, Orsini, N, Bellavia, A, Håkansson, N, Mu, L, Pastorino, R, Kurtz, RC, Derakhshan, MH, Lagiou, A, Lagiou, P, Boffetta, P, Boccia, S, Negri, E & La Vecchia, C 2018, 'Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project' European Journal of Cancer Prevention, vol. 27, no. 2, pp. 124-133. DOI: 10.1097/CEJ.0000000000000290

Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project. / Praud, Delphine; Rota, Matteo; Pelucchi, Claudio; Bertuccio, Paola; Rosso, Tiziana; Galeone, Carlotta; Zhang, Zuo Feng; Matsuo, Keitaro; Ito, Hidemi; Hu, Jinfu; Johnson, Kenneth C.; Yu, Guo Pei; Palli, Domenico; Ferraroni, Monica; Muscat, Joshua; Lunet, Nuno; Peleteiro, Bárbara; Malekzadeh, Reza; Ye, Weimin; Song, Huan; Zaridze, David; Maximovitch, Dmitry; Aragonés, Nuria; Castaño-Vinyals, Gemma; Vioque, Jesus; Navarrete-Muñoz, Eva M.; Pakseresht, Mohammadreza; Pourfarzi, Farhad; Wolk, Alicja; Orsini, Nicola; Bellavia, Andrea; Håkansson, Niclas; Mu, Lina; Pastorino, Roberta; Kurtz, Robert C.; Derakhshan, Mohammad H.; Lagiou, Areti; Lagiou, Pagona; Boffetta, Paolo; Boccia, Stefania; Negri, Eva; La Vecchia, Carlo.

In: European Journal of Cancer Prevention, Vol. 27, No. 2, 01.01.2018, p. 124-133.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Praud,Delphine

AU - Rota,Matteo

AU - Pelucchi,Claudio

AU - Bertuccio,Paola

AU - Rosso,Tiziana

AU - Galeone,Carlotta

AU - Zhang,Zuo Feng

AU - Matsuo,Keitaro

AU - Ito,Hidemi

AU - Hu,Jinfu

AU - Johnson,Kenneth C.

AU - Yu,Guo Pei

AU - Palli,Domenico

AU - Ferraroni,Monica

AU - Muscat,Joshua

AU - Lunet,Nuno

AU - Peleteiro,Bárbara

AU - Malekzadeh,Reza

AU - Ye,Weimin

AU - Song,Huan

AU - Zaridze,David

AU - Maximovitch,Dmitry

AU - Aragonés,Nuria

AU - Castaño-Vinyals,Gemma

AU - Vioque,Jesus

AU - Navarrete-Muñoz,Eva M.

AU - Pakseresht,Mohammadreza

AU - Pourfarzi,Farhad

AU - Wolk,Alicja

AU - Orsini,Nicola

AU - Bellavia,Andrea

AU - Håkansson,Niclas

AU - Mu,Lina

AU - Pastorino,Roberta

AU - Kurtz,Robert C.

AU - Derakhshan,Mohammad H.

AU - Lagiou,Areti

AU - Lagiou,Pagona

AU - Boffetta,Paolo

AU - Boccia,Stefania

AU - Negri,Eva

AU - La Vecchia,Carlo

PY - 2018/1/1

Y1 - 2018/1/1

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Praud D, Rota M, Pelucchi C, Bertuccio P, Rosso T, Galeone C et al. Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project. European Journal of Cancer Prevention. 2018 Jan 1;27(2):124-133. Available from, DOI: 10.1097/CEJ.0000000000000290