Abstract
Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the 'Stomach cancer Pooling (StoP) Project', including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95% CI: 1.09-1.32) for ever, 1.12 (95% CI: 0.99-1.27) for former, and 1.25 (95% CI: 1.11-1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95% CI: 1.10-1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95% CI: 1.14-1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (P for trend<0.01) and became similar to that of never smokers 10 years after stopping. Risks were somewhat higher for cardia than noncardia gastric cancer. Risks were similar when considering only studies with information on Helicobacter pylori infection and comparing all cases to H. pylori+ controls only. This study provides the most precise estimate of the detrimental effect of cigarette smoking on the risk of gastric cancer on the basis of individual data, including the relationship with dose and duration, and the decrease in risk following stopping smoking.
| Language | English (US) |
|---|---|
| Pages | 124-133 |
| Number of pages | 10 |
| Journal | European Journal of Cancer Prevention |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2018 |
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All Science Journal Classification (ASJC) codes
- Epidemiology
- Oncology
- Public Health, Environmental and Occupational Health
- Cancer Research
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Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project. / Praud, Delphine; Rota, Matteo; Pelucchi, Claudio; Bertuccio, Paola; Rosso, Tiziana; Galeone, Carlotta; Zhang, Zuo Feng; Matsuo, Keitaro; Ito, Hidemi; Hu, Jinfu; Johnson, Kenneth C.; Yu, Guo Pei; Palli, Domenico; Ferraroni, Monica; Muscat, Joshua; Lunet, Nuno; Peleteiro, Bárbara; Malekzadeh, Reza; Ye, Weimin; Song, Huan; Zaridze, David; Maximovitch, Dmitry; Aragonés, Nuria; Castaño-Vinyals, Gemma; Vioque, Jesus; Navarrete-Muñoz, Eva M.; Pakseresht, Mohammadreza; Pourfarzi, Farhad; Wolk, Alicja; Orsini, Nicola; Bellavia, Andrea; Håkansson, Niclas; Mu, Lina; Pastorino, Roberta; Kurtz, Robert C.; Derakhshan, Mohammad H.; Lagiou, Areti; Lagiou, Pagona; Boffetta, Paolo; Boccia, Stefania; Negri, Eva; La Vecchia, Carlo.
In: European Journal of Cancer Prevention, Vol. 27, No. 2, 01.01.2018, p. 124-133.Research output: Contribution to journal › Article
TY - JOUR
T1 - Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project
AU - Praud, Delphine
AU - Rota, Matteo
AU - Pelucchi, Claudio
AU - Bertuccio, Paola
AU - Rosso, Tiziana
AU - Galeone, Carlotta
AU - Zhang, Zuo Feng
AU - Matsuo, Keitaro
AU - Ito, Hidemi
AU - Hu, Jinfu
AU - Johnson, Kenneth C.
AU - Yu, Guo Pei
AU - Palli, Domenico
AU - Ferraroni, Monica
AU - Muscat, Joshua
AU - Lunet, Nuno
AU - Peleteiro, Bárbara
AU - Malekzadeh, Reza
AU - Ye, Weimin
AU - Song, Huan
AU - Zaridze, David
AU - Maximovitch, Dmitry
AU - Aragonés, Nuria
AU - Castaño-Vinyals, Gemma
AU - Vioque, Jesus
AU - Navarrete-Muñoz, Eva M.
AU - Pakseresht, Mohammadreza
AU - Pourfarzi, Farhad
AU - Wolk, Alicja
AU - Orsini, Nicola
AU - Bellavia, Andrea
AU - Håkansson, Niclas
AU - Mu, Lina
AU - Pastorino, Roberta
AU - Kurtz, Robert C.
AU - Derakhshan, Mohammad H.
AU - Lagiou, Areti
AU - Lagiou, Pagona
AU - Boffetta, Paolo
AU - Boccia, Stefania
AU - Negri, Eva
AU - La Vecchia, Carlo
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the 'Stomach cancer Pooling (StoP) Project', including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95% CI: 1.09-1.32) for ever, 1.12 (95% CI: 0.99-1.27) for former, and 1.25 (95% CI: 1.11-1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95% CI: 1.10-1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95% CI: 1.14-1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (P for trend<0.01) and became similar to that of never smokers 10 years after stopping. Risks were somewhat higher for cardia than noncardia gastric cancer. Risks were similar when considering only studies with information on Helicobacter pylori infection and comparing all cases to H. pylori+ controls only. This study provides the most precise estimate of the detrimental effect of cigarette smoking on the risk of gastric cancer on the basis of individual data, including the relationship with dose and duration, and the decrease in risk following stopping smoking.
AB - Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the 'Stomach cancer Pooling (StoP) Project', including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95% CI: 1.09-1.32) for ever, 1.12 (95% CI: 0.99-1.27) for former, and 1.25 (95% CI: 1.11-1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95% CI: 1.10-1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95% CI: 1.14-1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (P for trend<0.01) and became similar to that of never smokers 10 years after stopping. Risks were somewhat higher for cardia than noncardia gastric cancer. Risks were similar when considering only studies with information on Helicobacter pylori infection and comparing all cases to H. pylori+ controls only. This study provides the most precise estimate of the detrimental effect of cigarette smoking on the risk of gastric cancer on the basis of individual data, including the relationship with dose and duration, and the decrease in risk following stopping smoking.
UR - http://www.scopus.com/inward/record.url?scp=84983503522&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983503522&partnerID=8YFLogxK
U2 - 10.1097/CEJ.0000000000000290
DO - 10.1097/CEJ.0000000000000290
M3 - Article
VL - 27
SP - 124
EP - 133
JO - European Journal of Cancer Prevention
T2 - European Journal of Cancer Prevention
JF - European Journal of Cancer Prevention
SN - 0959-8278
IS - 2
ER -