Circadian rhythm of iguana electroretinogram: The role of dopamine and melatonin

Manuel Miranda-Anaya, Paul Allen Bartell, Michael Menaker

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The amplitude of the b-wave of the electroretinogram (ERG) varies with a circadian rhythm in the green iguana; the amplitude is high during the day (or subjective day) and low during the night (or subjective night). Dopamine and melatonin contents in the eye are robustly rhythmic under constant conditions; dopamine levels are high during the subjective day, and melatonin levels are high during the subjective night. Dopamine and melatonin affect the amplitude of the b-wave in an antagonistic and phase-dependent manner: dopamine D2-receptor agonists injected intraocularly during the subjective night produce high-amplitude b-waves characteristic of the subjective day, whereas melatonin injected intraocularly during the subjective day reduces b-wave amplitude. Sectioning the optic nerve abolishes the circadian rhythms of b-wave amplitude and of dopamine content. The results of this study suggest that in iguana, a negative feedback loop involving dopamine and melatonin regulates the circadian rhythm of the ERG b-wave amplitude that is at least in part generated in the brain.

Original languageEnglish (US)
Pages (from-to)526-538
Number of pages13
JournalJournal of Biological Rhythms
Volume17
Issue number6
DOIs
StatePublished - Dec 1 2002

Fingerprint

Iguanas
Melatonin
Circadian Rhythm
Dopamine
Dopamine D2 Receptors
Dopamine Agonists
Optic Nerve
Brain

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

@article{9ced27de411642d8bedfb3eb6ad1045e,
title = "Circadian rhythm of iguana electroretinogram: The role of dopamine and melatonin",
abstract = "The amplitude of the b-wave of the electroretinogram (ERG) varies with a circadian rhythm in the green iguana; the amplitude is high during the day (or subjective day) and low during the night (or subjective night). Dopamine and melatonin contents in the eye are robustly rhythmic under constant conditions; dopamine levels are high during the subjective day, and melatonin levels are high during the subjective night. Dopamine and melatonin affect the amplitude of the b-wave in an antagonistic and phase-dependent manner: dopamine D2-receptor agonists injected intraocularly during the subjective night produce high-amplitude b-waves characteristic of the subjective day, whereas melatonin injected intraocularly during the subjective day reduces b-wave amplitude. Sectioning the optic nerve abolishes the circadian rhythms of b-wave amplitude and of dopamine content. The results of this study suggest that in iguana, a negative feedback loop involving dopamine and melatonin regulates the circadian rhythm of the ERG b-wave amplitude that is at least in part generated in the brain.",
author = "Manuel Miranda-Anaya and Bartell, {Paul Allen} and Michael Menaker",
year = "2002",
month = "12",
day = "1",
doi = "10.1177/0748730402238235",
language = "English (US)",
volume = "17",
pages = "526--538",
journal = "Journal of Biological Rhythms",
issn = "0748-7304",
publisher = "SAGE Publications Inc.",
number = "6",

}

Circadian rhythm of iguana electroretinogram : The role of dopamine and melatonin. / Miranda-Anaya, Manuel; Bartell, Paul Allen; Menaker, Michael.

In: Journal of Biological Rhythms, Vol. 17, No. 6, 01.12.2002, p. 526-538.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Circadian rhythm of iguana electroretinogram

T2 - The role of dopamine and melatonin

AU - Miranda-Anaya, Manuel

AU - Bartell, Paul Allen

AU - Menaker, Michael

PY - 2002/12/1

Y1 - 2002/12/1

N2 - The amplitude of the b-wave of the electroretinogram (ERG) varies with a circadian rhythm in the green iguana; the amplitude is high during the day (or subjective day) and low during the night (or subjective night). Dopamine and melatonin contents in the eye are robustly rhythmic under constant conditions; dopamine levels are high during the subjective day, and melatonin levels are high during the subjective night. Dopamine and melatonin affect the amplitude of the b-wave in an antagonistic and phase-dependent manner: dopamine D2-receptor agonists injected intraocularly during the subjective night produce high-amplitude b-waves characteristic of the subjective day, whereas melatonin injected intraocularly during the subjective day reduces b-wave amplitude. Sectioning the optic nerve abolishes the circadian rhythms of b-wave amplitude and of dopamine content. The results of this study suggest that in iguana, a negative feedback loop involving dopamine and melatonin regulates the circadian rhythm of the ERG b-wave amplitude that is at least in part generated in the brain.

AB - The amplitude of the b-wave of the electroretinogram (ERG) varies with a circadian rhythm in the green iguana; the amplitude is high during the day (or subjective day) and low during the night (or subjective night). Dopamine and melatonin contents in the eye are robustly rhythmic under constant conditions; dopamine levels are high during the subjective day, and melatonin levels are high during the subjective night. Dopamine and melatonin affect the amplitude of the b-wave in an antagonistic and phase-dependent manner: dopamine D2-receptor agonists injected intraocularly during the subjective night produce high-amplitude b-waves characteristic of the subjective day, whereas melatonin injected intraocularly during the subjective day reduces b-wave amplitude. Sectioning the optic nerve abolishes the circadian rhythms of b-wave amplitude and of dopamine content. The results of this study suggest that in iguana, a negative feedback loop involving dopamine and melatonin regulates the circadian rhythm of the ERG b-wave amplitude that is at least in part generated in the brain.

UR - http://www.scopus.com/inward/record.url?scp=0141508973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141508973&partnerID=8YFLogxK

U2 - 10.1177/0748730402238235

DO - 10.1177/0748730402238235

M3 - Article

C2 - 12465886

AN - SCOPUS:0141508973

VL - 17

SP - 526

EP - 538

JO - Journal of Biological Rhythms

JF - Journal of Biological Rhythms

SN - 0748-7304

IS - 6

ER -