Circulating plasma leptin and IGF-1 levels in girls with premature adrenarche: Potential implications of a preliminary study

G. Cizza, L. D. Dorn, A. Lotsikas, S. Sereika, D. Rotenstein, G. P. Chrousos

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Premature adrenarche is a condition characterized by precocious development of pubic and/or axillary hair, due to early onset of adrenal androgen secretion. Girls with premature adrenarche may later develop menstrual irregularities, hyperandrogenism, and the classic polycystic ovary syndrome. As leptin is thought to modulate the onset of pubertal development, we measured plasma leptin levels in 7 girls with premature adrenarche, and 8 age-matched comparison girls. Because leptin, the hypothalamic-pituitary-adrenal (HPA), the hypothalamic-pituitary-gonadal axes are functionally interrelated, we also determined salivary and plasma cortisol, dehydroepiandrosterone (DHEA), DHEA-sulfate, androstenedione, estradiol, and estrone. Finally, since IGF-I may play a role in adrenocortical function, we determined plasma levels of IGF-1, and IGF-BP1. Plasma was collected by an intravenous catheter at times 0, 20, and 40 min, starting at 1.30 p.m. Girls with premature adrenarche had a higher body mass index (BMI) and an over two-fold elevation of their plasma leptin than comparison girls. This group also had elevated levels of salivary and plasma cortisol, and increased levels of DHEA, DHEA-S, androstenedione, estradiol and estrone. Plasma IGF-1 and the ratio of IGF-1/IGF-BP1 were elevated. We propose that girls with premature adrenarche may represent an overlapping group characterized by both features of increased adiposity and HPA axis activity, which together, and depending on the genetic/constitutional background of the individual, may account for the development of adrenal hyperandrogenism, and, later, the polycystic ovary syndrome.

Original languageEnglish (US)
Pages (from-to)138-143
Number of pages6
JournalHormone and Metabolic Research
Volume33
Issue number3
DOIs
StatePublished - May 22 2001

Fingerprint

Adrenarche
Leptin
Insulin-Like Growth Factor I
Plasmas
Dehydroepiandrosterone
Hyperandrogenism
Androstenedione
Estrone
Polycystic Ovary Syndrome
Hydrocortisone
Estradiol
Dehydroepiandrosterone Sulfate
Catheters
Adiposity
Hair
Androgens
Body Mass Index

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Cizza, G. ; Dorn, L. D. ; Lotsikas, A. ; Sereika, S. ; Rotenstein, D. ; Chrousos, G. P. / Circulating plasma leptin and IGF-1 levels in girls with premature adrenarche : Potential implications of a preliminary study. In: Hormone and Metabolic Research. 2001 ; Vol. 33, No. 3. pp. 138-143.
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Circulating plasma leptin and IGF-1 levels in girls with premature adrenarche : Potential implications of a preliminary study. / Cizza, G.; Dorn, L. D.; Lotsikas, A.; Sereika, S.; Rotenstein, D.; Chrousos, G. P.

In: Hormone and Metabolic Research, Vol. 33, No. 3, 22.05.2001, p. 138-143.

Research output: Contribution to journalArticle

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AU - Cizza, G.

AU - Dorn, L. D.

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AU - Rotenstein, D.

AU - Chrousos, G. P.

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