Citrate-Based Tannin-Bridged Bone Composites for Lumbar Fusion

Jinshan Guo, Xinggui Tian, Denghui Xie, Kevin Rahn, Ethan Gerhard, Michelle Laurel Kuzma, Dongfang Zhou, Cheng Dong, Xiaochun Bai, Zhihui Lu, Jian Yang

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Conventional bone composites consistently fail to mimic the chemical composition and integrated organic/inorganic structure of natural bone, lacking sufficient mechanics as well as inherent osteoconductivity and osteoinductivity. Through a facile surface coating process, the strong adhesive, tannic acid (TA), is adhered to the surface of the natural bone component, hydroxyapatite (HA), with and without the immobilization of in situ formed silver nanoparticles. Residual functional groups available on the immobilized TA substituents are subsequently covalently linked to the citrate-based biodegradable polymer, poly(octamethylene citrate) (POC), effectively bridging the organic and inorganic phases. Due to the synergistic effects of the tannin and citrate components, the obtained citrate-based tannin-bridged bone composites (CTBCs) exhibit vastly improved compression strengths up to 323.0 ± 21.3 MPa compared to 229.9 ± 15.6 MPa for POC-HA, and possess tunable degradation profiles, enhanced biomineralization performance, favorable biocompatibility, increased cell adhesion and proliferation, as well as considerable antimicrobial activity. In vivo study of porous CTBCs using a lumbar fusion model further confirms CTBCs' osteoconductivity and osteoinductivity, promoting bone regeneration. CTBCs possess great potential for bone regeneration applications while the immobilized TA additionally preserves surface bioconjugation sites to further tailor the bioactivity of CTBCs.

Original languageEnglish (US)
Article number2002438
JournalAdvanced Functional Materials
Volume30
Issue number27
DOIs
StatePublished - Jul 1 2020

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Citrate-Based Tannin-Bridged Bone Composites for Lumbar Fusion'. Together they form a unique fingerprint.

  • Cite this

    Guo, J., Tian, X., Xie, D., Rahn, K., Gerhard, E., Kuzma, M. L., Zhou, D., Dong, C., Bai, X., Lu, Z., & Yang, J. (2020). Citrate-Based Tannin-Bridged Bone Composites for Lumbar Fusion. Advanced Functional Materials, 30(27), [2002438]. https://doi.org/10.1002/adfm.202002438