Citric acid-based elastomers provide a biocompatible interface for vascular grafts

Melina R. Kibbe, Janet Martinez, Daniel A. Popowich, Muneera R. Kapadia, Sadaf S. Ahanchi, Oliver O. Aalami, Qun Jiang, Antonio R. Webb, Jian Yang, Timothy Carroll, Guillermo A. Ameer

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Prosthetic vascular bypass grafting is associated with poor long-term patency rates. Herein, we report on the mid-term performance of expanded polytetrafluoroethylene (ePTFE) vascular grafts modified with a citric acidbased biodegradable elastomer. Through a spin-shearing method, ePTFE grafts were modified by mechanically coating a layer of poly(1,8 octanediol citrate) (POC) onto the luminal nodes and fibrils of the ePTFE. Control and POC-ePTFE grafts were implanted into the porcine carotid artery circulation as end-to-side bypass grafts. Grafts were assessed by duplex ultrasonography, magnetic resonance angiography, and digital subtraction contrast angiography and were all found to be patent with no hemodynamically significant stenoses. At 4 weeks, POC-ePTFE grafts were found to be biocompatible and resulted in a similar extent of neointimal hyperplasia as well as leukocyte and monocyte/macrophage infiltration as control ePTFE grafts. Furthermore, POC supported endothelial cell growth. Lastly, scanning electron microscopy confirmed the presence of POC on the ePTFE grafts at 4 weeks. Thus, these data reveal that surface modification of blood-contacting surfaces with POC results in a biocompatible surface that does not induce any untoward effects or inflammation in the vasculature. These findings are important as they will serve as the foundation for the development of a drug-eluting vascular graft.

Original languageEnglish (US)
Pages (from-to)314-324
Number of pages11
JournalJournal of Biomedical Materials Research - Part A
Volume93
Issue number1
DOIs
StatePublished - Apr 1 2010

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

Fingerprint Dive into the research topics of 'Citric acid-based elastomers provide a biocompatible interface for vascular grafts'. Together they form a unique fingerprint.

  • Cite this

    Kibbe, M. R., Martinez, J., Popowich, D. A., Kapadia, M. R., Ahanchi, S. S., Aalami, O. O., Jiang, Q., Webb, A. R., Yang, J., Carroll, T., & Ameer, G. A. (2010). Citric acid-based elastomers provide a biocompatible interface for vascular grafts. Journal of Biomedical Materials Research - Part A, 93(1), 314-324. https://doi.org/10.1002/jbm.a.32537