Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration

Dawei Sun, Yuhui Chen, Richard T. Tran, Song Xu, Denghui Xie, Chunhong Jia, Yuchen Wang, Ying Guo, Zhongmin Zhang, Jinshan Guo, Jian Yang, Dadi Jin, Xiaochun Bai

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Citric acid-based polymer/hydroxyapatite composites (CABP-HAs) are a novel class of biomimetic composites that have recently attracted significant attention in tissue engineering. The objective of this study was to compare the efficacy of using two different CABP-HAs, poly (1,8-octanediol citrate)-click-HA (POC-Click-HA) and crosslinked urethane-doped polyester-HA (CUPE-HA) as an alternative to autologous tissue grafts in the repair of skeletal defects. CABP-HA disc-shaped scaffolds (65 wt.-% HA with 70% porosity) were used as bare implants without the addition of growth factors or cells to renovate 4â€...mm diameter rat calvarial defects (n = 72, n = 18 per group). Defects were either left empty (negative control group), or treated with CUPE-HA scaffolds, POC-Click-HA scaffolds, or autologous bone grafts (AB group). Radiological and histological data showed a significant enhancement of osteogenesis in defects treated with CUPE-HA scaffolds when compared to POC-Click-HA scaffolds. Both, POC-Click-HA and CUPE-HA scaffolds, resulted in enhanced bone mineral density, trabecular thickness, and angiogenesis when compared to the control groups at 1, 3, and 6 months post-trauma. These results show the potential of CABP-HA bare implants as biocompatible, osteogenic, and off-shelf-available options in the repair of orthopedic defects.

Original languageEnglish (US)
Article number6912
JournalScientific reports
Volume4
DOIs
StatePublished - Nov 5 2014

Fingerprint

Polyesters
Urethane
Durapatite
Citric Acid
Regeneration
Polymers
Transplants
Biomimetics
Control Groups
Porosity
Tissue Engineering
Osteogenesis
Bone Density
Orthopedics
Intercellular Signaling Peptides and Proteins
Bone and Bones
poly(1,8-octanediol citrate)
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • General

Cite this

Sun, D., Chen, Y., Tran, R. T., Xu, S., Xie, D., Jia, C., ... Bai, X. (2014). Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration. Scientific reports, 4, [6912]. https://doi.org/10.1038/srep06912
Sun, Dawei ; Chen, Yuhui ; Tran, Richard T. ; Xu, Song ; Xie, Denghui ; Jia, Chunhong ; Wang, Yuchen ; Guo, Ying ; Zhang, Zhongmin ; Guo, Jinshan ; Yang, Jian ; Jin, Dadi ; Bai, Xiaochun. / Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration. In: Scientific reports. 2014 ; Vol. 4.
@article{d80a23708f3a4242ba60da7ca4d11881,
title = "Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration",
abstract = "Citric acid-based polymer/hydroxyapatite composites (CABP-HAs) are a novel class of biomimetic composites that have recently attracted significant attention in tissue engineering. The objective of this study was to compare the efficacy of using two different CABP-HAs, poly (1,8-octanediol citrate)-click-HA (POC-Click-HA) and crosslinked urethane-doped polyester-HA (CUPE-HA) as an alternative to autologous tissue grafts in the repair of skeletal defects. CABP-HA disc-shaped scaffolds (65 wt.-{\%} HA with 70{\%} porosity) were used as bare implants without the addition of growth factors or cells to renovate 4{\^a}€...mm diameter rat calvarial defects (n = 72, n = 18 per group). Defects were either left empty (negative control group), or treated with CUPE-HA scaffolds, POC-Click-HA scaffolds, or autologous bone grafts (AB group). Radiological and histological data showed a significant enhancement of osteogenesis in defects treated with CUPE-HA scaffolds when compared to POC-Click-HA scaffolds. Both, POC-Click-HA and CUPE-HA scaffolds, resulted in enhanced bone mineral density, trabecular thickness, and angiogenesis when compared to the control groups at 1, 3, and 6 months post-trauma. These results show the potential of CABP-HA bare implants as biocompatible, osteogenic, and off-shelf-available options in the repair of orthopedic defects.",
author = "Dawei Sun and Yuhui Chen and Tran, {Richard T.} and Song Xu and Denghui Xie and Chunhong Jia and Yuchen Wang and Ying Guo and Zhongmin Zhang and Jinshan Guo and Jian Yang and Dadi Jin and Xiaochun Bai",
year = "2014",
month = "11",
day = "5",
doi = "10.1038/srep06912",
language = "English (US)",
volume = "4",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

Sun, D, Chen, Y, Tran, RT, Xu, S, Xie, D, Jia, C, Wang, Y, Guo, Y, Zhang, Z, Guo, J, Yang, J, Jin, D & Bai, X 2014, 'Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration', Scientific reports, vol. 4, 6912. https://doi.org/10.1038/srep06912

Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration. / Sun, Dawei; Chen, Yuhui; Tran, Richard T.; Xu, Song; Xie, Denghui; Jia, Chunhong; Wang, Yuchen; Guo, Ying; Zhang, Zhongmin; Guo, Jinshan; Yang, Jian; Jin, Dadi; Bai, Xiaochun.

In: Scientific reports, Vol. 4, 6912, 05.11.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Citric acid-based hydroxyapatite composite scaffolds enhance calvarial regeneration

AU - Sun, Dawei

AU - Chen, Yuhui

AU - Tran, Richard T.

AU - Xu, Song

AU - Xie, Denghui

AU - Jia, Chunhong

AU - Wang, Yuchen

AU - Guo, Ying

AU - Zhang, Zhongmin

AU - Guo, Jinshan

AU - Yang, Jian

AU - Jin, Dadi

AU - Bai, Xiaochun

PY - 2014/11/5

Y1 - 2014/11/5

N2 - Citric acid-based polymer/hydroxyapatite composites (CABP-HAs) are a novel class of biomimetic composites that have recently attracted significant attention in tissue engineering. The objective of this study was to compare the efficacy of using two different CABP-HAs, poly (1,8-octanediol citrate)-click-HA (POC-Click-HA) and crosslinked urethane-doped polyester-HA (CUPE-HA) as an alternative to autologous tissue grafts in the repair of skeletal defects. CABP-HA disc-shaped scaffolds (65 wt.-% HA with 70% porosity) were used as bare implants without the addition of growth factors or cells to renovate 4â€...mm diameter rat calvarial defects (n = 72, n = 18 per group). Defects were either left empty (negative control group), or treated with CUPE-HA scaffolds, POC-Click-HA scaffolds, or autologous bone grafts (AB group). Radiological and histological data showed a significant enhancement of osteogenesis in defects treated with CUPE-HA scaffolds when compared to POC-Click-HA scaffolds. Both, POC-Click-HA and CUPE-HA scaffolds, resulted in enhanced bone mineral density, trabecular thickness, and angiogenesis when compared to the control groups at 1, 3, and 6 months post-trauma. These results show the potential of CABP-HA bare implants as biocompatible, osteogenic, and off-shelf-available options in the repair of orthopedic defects.

AB - Citric acid-based polymer/hydroxyapatite composites (CABP-HAs) are a novel class of biomimetic composites that have recently attracted significant attention in tissue engineering. The objective of this study was to compare the efficacy of using two different CABP-HAs, poly (1,8-octanediol citrate)-click-HA (POC-Click-HA) and crosslinked urethane-doped polyester-HA (CUPE-HA) as an alternative to autologous tissue grafts in the repair of skeletal defects. CABP-HA disc-shaped scaffolds (65 wt.-% HA with 70% porosity) were used as bare implants without the addition of growth factors or cells to renovate 4â€...mm diameter rat calvarial defects (n = 72, n = 18 per group). Defects were either left empty (negative control group), or treated with CUPE-HA scaffolds, POC-Click-HA scaffolds, or autologous bone grafts (AB group). Radiological and histological data showed a significant enhancement of osteogenesis in defects treated with CUPE-HA scaffolds when compared to POC-Click-HA scaffolds. Both, POC-Click-HA and CUPE-HA scaffolds, resulted in enhanced bone mineral density, trabecular thickness, and angiogenesis when compared to the control groups at 1, 3, and 6 months post-trauma. These results show the potential of CABP-HA bare implants as biocompatible, osteogenic, and off-shelf-available options in the repair of orthopedic defects.

UR - http://www.scopus.com/inward/record.url?scp=84923233784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923233784&partnerID=8YFLogxK

U2 - 10.1038/srep06912

DO - 10.1038/srep06912

M3 - Article

C2 - 25372769

AN - SCOPUS:84923233784

VL - 4

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 6912

ER -