Class i major histocompatibility complex genes of the red-necked wallaby, macropus rufogriseus

Werner E. Mayer, Noelle Sevilir Williams, Colm O’Huigin, Vladimir Vincek, Zofia Zaleska-Rutczynska, Jan Klein

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Marsupials are one of three main evolutionary lineages in mammals, the other two being the monotremes and the placental mammals. The marsupial and the placental lineages separated between 120 and 156 million years ago. In this communication, we provide the first molecular description of class I major histocompatibility complex (Mhc) genes in a representative of the marsupial lineage, the red-necked wallaby, Macropus rufogriseus. Three different, nearly full-length class I Mhc sequences were identified in the cDNA library prepared from spleen mRNA of a single wallaby. The three sequences identify at least two loci. Under the assumption that two of the identified sequences are alleles, we designate the three wallaby genes Maru-Mhc-UA*01, Maru-Mhc-UA*02, and Maru-Mhc-UB*01. The three Maru sequences share several codon deletions and insertions not found in the class I genes of placental mammals. Comparisons of genetic distances among the known class I genes suggest that the Maru genes arose from one ancestral element, whereas the class I genes of the placental mammals arose from another, different ancestral element. The absence of an identifiable defect in the three Maru sequences suggests that the genes from which they were derived are functional. Hence, as in placental mammals, there appear to be two functional class I Mhc loci in the marsupials as well.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalMolecular Phylogenetics and Evolution
Volume2
Issue number1
DOIs
StatePublished - Mar 1993

Fingerprint

Macropus rufogriseus
Macropodidae
major histocompatibility complex
Major Histocompatibility Complex
Marsupialia
Mammals
Metatheria
MHC Class I Genes
marsupial
mammals
gene
mammal
Genes
genes
monotreme
loci
Gene Library
codons
Codon
cDNA libraries

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

Mayer, W. E., Williams, N. S., O’Huigin, C., Vincek, V., Zaleska-Rutczynska, Z., & Klein, J. (1993). Class i major histocompatibility complex genes of the red-necked wallaby, macropus rufogriseus. Molecular Phylogenetics and Evolution, 2(1), 23-30. https://doi.org/10.1006/mpev.1993.1004
Mayer, Werner E. ; Williams, Noelle Sevilir ; O’Huigin, Colm ; Vincek, Vladimir ; Zaleska-Rutczynska, Zofia ; Klein, Jan. / Class i major histocompatibility complex genes of the red-necked wallaby, macropus rufogriseus. In: Molecular Phylogenetics and Evolution. 1993 ; Vol. 2, No. 1. pp. 23-30.
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Mayer, WE, Williams, NS, O’Huigin, C, Vincek, V, Zaleska-Rutczynska, Z & Klein, J 1993, 'Class i major histocompatibility complex genes of the red-necked wallaby, macropus rufogriseus', Molecular Phylogenetics and Evolution, vol. 2, no. 1, pp. 23-30. https://doi.org/10.1006/mpev.1993.1004

Class i major histocompatibility complex genes of the red-necked wallaby, macropus rufogriseus. / Mayer, Werner E.; Williams, Noelle Sevilir; O’Huigin, Colm; Vincek, Vladimir; Zaleska-Rutczynska, Zofia; Klein, Jan.

In: Molecular Phylogenetics and Evolution, Vol. 2, No. 1, 03.1993, p. 23-30.

Research output: Contribution to journalArticle

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