Clinical and biological features of multiple myeloma involving the gastrointestinal system

Giampaolo Talamo, Federica Cavallo, Maurizio Zangari, Bart Barlogie, Choon Kee Lee, Mauricio Pineda-Roman, Elias Kiwan, Somashekar Krishna, Guido Tricot

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Abstract

We report 24 cases of multiple myeloma (MM) with involvement of the gastrointestinal (GI) system. We found a strong association with high lactate dehydrogenase levels, plasmablastic morphology, and unfavorable karyotype. GI involvement at the time of initial diagnosis was much rarer than later in the course of the disease. The median survival after diagnosis of GI involvement was 7 months. Among 13 patients treated with stem cell transplantation, the response rate was 92%, and median progression-free survival was 4 months. We conclude that MM involving the GI system is associated with adverse biological features and with short-lasting remissions, even after high-dose chemotherapy.

Original languageEnglish (US)
Pages (from-to)964-967
Number of pages4
JournalHaematologica
Volume91
Issue number7
StatePublished - Jul 1 2006

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All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Talamo, G., Cavallo, F., Zangari, M., Barlogie, B., Lee, C. K., Pineda-Roman, M., Kiwan, E., Krishna, S., & Tricot, G. (2006). Clinical and biological features of multiple myeloma involving the gastrointestinal system. Haematologica, 91(7), 964-967.