Clinical and functional characteristics of subjects with asthma, COPD, and asthma-COPD Overlap: A multicentre study in Vietnam

Sy Duong-Quy, Huong Tran Van, Anh Vo Thi Kim, Quyen Pham Huy, Timothy J. Craig

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction. Subjects with asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) share common features of patients with asthma and COPD. Our study was planned to describe the clinical and functional features of subjects with ACO compared to asthma and COPD patients. Subjects and Methods. Study subjects who met the inclusion criteria were classified into three different groups: Asthma, COPD, and ACO groups. All study subjects underwent clinical examination and biological and functional testing. They were then followed for 6 months to evaluate the response to conventional treatment. Results. From March 2015 to March 2017, 76 asthmatic (mean age: 41 ± 22 years), 74 COPD (59 ± 13 years), and 59 ACO (52 ± 14 years) subjects were included. The percentage of subjects with dyspnea on excretion in the ACO group was higher than that in asthma and COPD groups (P<0.001 and P<0.05, resp.). Subjects with COPD and ACO had significant airflow limitation (FEV 1 ) compared to asthma (64 ± 17% and 54 ± 14% versus 80 ± 22%; P<0.01 and P<0.01, resp.). The levels of FENO in subjects with asthma and ACO were significantly higher than those in subjects with COPD (46 ± 28 ppb and 34 ± 12 ppb versus 15 ± 8 ppb; P<0.001 and P<0.001, resp.). VO 2 max and 6MWD were improved in study subjects after 6 months of treatment. Increased CANO and AHI > 15/hour had a significant probability of risk for ACO (OR = 33.2, P<0.001, and OR = 3.4, P<0.05, resp.). Conclusion. Subjects with ACO share the common clinical and functional characteristics of asthma and COPD but are more likely to have sleep apnea. The majority of patients with ACO have a favourable response to combined treatment.

Original languageEnglish (US)
Article number1732946
JournalCanadian Respiratory Journal
Volume2018
DOIs
StatePublished - Jan 1 2018

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Vietnam
Chronic Obstructive Pulmonary Disease
Multicenter Studies
Asthma
Sleep Apnea Syndromes
Dyspnea
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

@article{6d2526f306ce4bceafc7a3649b3bb219,
title = "Clinical and functional characteristics of subjects with asthma, COPD, and asthma-COPD Overlap: A multicentre study in Vietnam",
abstract = "Introduction. Subjects with asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) share common features of patients with asthma and COPD. Our study was planned to describe the clinical and functional features of subjects with ACO compared to asthma and COPD patients. Subjects and Methods. Study subjects who met the inclusion criteria were classified into three different groups: Asthma, COPD, and ACO groups. All study subjects underwent clinical examination and biological and functional testing. They were then followed for 6 months to evaluate the response to conventional treatment. Results. From March 2015 to March 2017, 76 asthmatic (mean age: 41 ± 22 years), 74 COPD (59 ± 13 years), and 59 ACO (52 ± 14 years) subjects were included. The percentage of subjects with dyspnea on excretion in the ACO group was higher than that in asthma and COPD groups (P<0.001 and P<0.05, resp.). Subjects with COPD and ACO had significant airflow limitation (FEV 1 ) compared to asthma (64 ± 17{\%} and 54 ± 14{\%} versus 80 ± 22{\%}; P<0.01 and P<0.01, resp.). The levels of FENO in subjects with asthma and ACO were significantly higher than those in subjects with COPD (46 ± 28 ppb and 34 ± 12 ppb versus 15 ± 8 ppb; P<0.001 and P<0.001, resp.). VO 2 max and 6MWD were improved in study subjects after 6 months of treatment. Increased CANO and AHI > 15/hour had a significant probability of risk for ACO (OR = 33.2, P<0.001, and OR = 3.4, P<0.05, resp.). Conclusion. Subjects with ACO share the common clinical and functional characteristics of asthma and COPD but are more likely to have sleep apnea. The majority of patients with ACO have a favourable response to combined treatment.",
author = "Sy Duong-Quy and {Tran Van}, Huong and {Vo Thi Kim}, Anh and {Pham Huy}, Quyen and Craig, {Timothy J.}",
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Clinical and functional characteristics of subjects with asthma, COPD, and asthma-COPD Overlap : A multicentre study in Vietnam. / Duong-Quy, Sy; Tran Van, Huong; Vo Thi Kim, Anh; Pham Huy, Quyen; Craig, Timothy J.

In: Canadian Respiratory Journal, Vol. 2018, 1732946, 01.01.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical and functional characteristics of subjects with asthma, COPD, and asthma-COPD Overlap

T2 - A multicentre study in Vietnam

AU - Duong-Quy, Sy

AU - Tran Van, Huong

AU - Vo Thi Kim, Anh

AU - Pham Huy, Quyen

AU - Craig, Timothy J.

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N2 - Introduction. Subjects with asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) share common features of patients with asthma and COPD. Our study was planned to describe the clinical and functional features of subjects with ACO compared to asthma and COPD patients. Subjects and Methods. Study subjects who met the inclusion criteria were classified into three different groups: Asthma, COPD, and ACO groups. All study subjects underwent clinical examination and biological and functional testing. They were then followed for 6 months to evaluate the response to conventional treatment. Results. From March 2015 to March 2017, 76 asthmatic (mean age: 41 ± 22 years), 74 COPD (59 ± 13 years), and 59 ACO (52 ± 14 years) subjects were included. The percentage of subjects with dyspnea on excretion in the ACO group was higher than that in asthma and COPD groups (P<0.001 and P<0.05, resp.). Subjects with COPD and ACO had significant airflow limitation (FEV 1 ) compared to asthma (64 ± 17% and 54 ± 14% versus 80 ± 22%; P<0.01 and P<0.01, resp.). The levels of FENO in subjects with asthma and ACO were significantly higher than those in subjects with COPD (46 ± 28 ppb and 34 ± 12 ppb versus 15 ± 8 ppb; P<0.001 and P<0.001, resp.). VO 2 max and 6MWD were improved in study subjects after 6 months of treatment. Increased CANO and AHI > 15/hour had a significant probability of risk for ACO (OR = 33.2, P<0.001, and OR = 3.4, P<0.05, resp.). Conclusion. Subjects with ACO share the common clinical and functional characteristics of asthma and COPD but are more likely to have sleep apnea. The majority of patients with ACO have a favourable response to combined treatment.

AB - Introduction. Subjects with asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) share common features of patients with asthma and COPD. Our study was planned to describe the clinical and functional features of subjects with ACO compared to asthma and COPD patients. Subjects and Methods. Study subjects who met the inclusion criteria were classified into three different groups: Asthma, COPD, and ACO groups. All study subjects underwent clinical examination and biological and functional testing. They were then followed for 6 months to evaluate the response to conventional treatment. Results. From March 2015 to March 2017, 76 asthmatic (mean age: 41 ± 22 years), 74 COPD (59 ± 13 years), and 59 ACO (52 ± 14 years) subjects were included. The percentage of subjects with dyspnea on excretion in the ACO group was higher than that in asthma and COPD groups (P<0.001 and P<0.05, resp.). Subjects with COPD and ACO had significant airflow limitation (FEV 1 ) compared to asthma (64 ± 17% and 54 ± 14% versus 80 ± 22%; P<0.01 and P<0.01, resp.). The levels of FENO in subjects with asthma and ACO were significantly higher than those in subjects with COPD (46 ± 28 ppb and 34 ± 12 ppb versus 15 ± 8 ppb; P<0.001 and P<0.001, resp.). VO 2 max and 6MWD were improved in study subjects after 6 months of treatment. Increased CANO and AHI > 15/hour had a significant probability of risk for ACO (OR = 33.2, P<0.001, and OR = 3.4, P<0.05, resp.). Conclusion. Subjects with ACO share the common clinical and functional characteristics of asthma and COPD but are more likely to have sleep apnea. The majority of patients with ACO have a favourable response to combined treatment.

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