Clinical and Microbiologic Characterization of Hemorrhagic Pneumonia Due to Extraintestinal Pathogenic Escherichia coli in Four Young Dogs

Larry K. Handt, Dana A. Stoffregen, Judith S. Prescott, Walter J. Pouch, David T.W. Ngai, Charles A. Anderson, Nicholas T. Gatto, Chitrita Debroy, John M. Fairbrother, Sherri L. Motzel, Hilton J. Klein

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Over a 21-month period, three Beagle dogs and one mixed-breed dog at our facility developed fatal pneumonia. The four dogs, all purpose bred, came from three vendors and had received the standard canine vaccines prior to shipment. In each instance, the affected dog had been shipped to our facility within the past 10 days. Three cases presented as a peracute clinical syndrome, and all had gross and microscopic findings consistent with hemorrhagic pneumonia. Escherichia coli was isolated from the lungs of all four dogs. Results of testing of lung tissue for canine parainfluenza virus and canine adenovirus were negative. Escherichia coli was also isolated from blood of three of the four dogs. Serotyping of the E. coli isolates indicated that two were serotype 06 and two were 04. Isolates from all four dogs were positive for the virulence factors alpha hemolysin and cytotoxic necrotizing factor 1 and for the adhesin factor class-III papG allele. These traits place the isolates in the class of extraintestinal pathogenic E. coli, which is being increasingly implicated as a cause of extraintestinal infections in animals and humans and may represent a zoonotic risk to humans working with research dogs.

Original languageEnglish (US)
Pages (from-to)663-670
Number of pages8
JournalComparative Medicine
Volume53
Issue number6
StatePublished - Dec 1 2003

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Escherichia coli
pneumonia
Pneumonia
Dogs
dogs
Hemolysin Proteins
Virulence Factors
Viruses
Canidae
Animals
Canine Adenoviruses
Blood
Vaccines
Tissue
Paramyxoviridae Infections
Serotyping
Lung
lungs
Extraintestinal Pathogenic Escherichia coli
Canine adenovirus A

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Handt, L. K., Stoffregen, D. A., Prescott, J. S., Pouch, W. J., Ngai, D. T. W., Anderson, C. A., ... Klein, H. J. (2003). Clinical and Microbiologic Characterization of Hemorrhagic Pneumonia Due to Extraintestinal Pathogenic Escherichia coli in Four Young Dogs. Comparative Medicine, 53(6), 663-670.
Handt, Larry K. ; Stoffregen, Dana A. ; Prescott, Judith S. ; Pouch, Walter J. ; Ngai, David T.W. ; Anderson, Charles A. ; Gatto, Nicholas T. ; Debroy, Chitrita ; Fairbrother, John M. ; Motzel, Sherri L. ; Klein, Hilton J. / Clinical and Microbiologic Characterization of Hemorrhagic Pneumonia Due to Extraintestinal Pathogenic Escherichia coli in Four Young Dogs. In: Comparative Medicine. 2003 ; Vol. 53, No. 6. pp. 663-670.
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Handt, LK, Stoffregen, DA, Prescott, JS, Pouch, WJ, Ngai, DTW, Anderson, CA, Gatto, NT, Debroy, C, Fairbrother, JM, Motzel, SL & Klein, HJ 2003, 'Clinical and Microbiologic Characterization of Hemorrhagic Pneumonia Due to Extraintestinal Pathogenic Escherichia coli in Four Young Dogs', Comparative Medicine, vol. 53, no. 6, pp. 663-670.

Clinical and Microbiologic Characterization of Hemorrhagic Pneumonia Due to Extraintestinal Pathogenic Escherichia coli in Four Young Dogs. / Handt, Larry K.; Stoffregen, Dana A.; Prescott, Judith S.; Pouch, Walter J.; Ngai, David T.W.; Anderson, Charles A.; Gatto, Nicholas T.; Debroy, Chitrita; Fairbrother, John M.; Motzel, Sherri L.; Klein, Hilton J.

In: Comparative Medicine, Vol. 53, No. 6, 01.12.2003, p. 663-670.

Research output: Contribution to journalArticle

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Handt LK, Stoffregen DA, Prescott JS, Pouch WJ, Ngai DTW, Anderson CA et al. Clinical and Microbiologic Characterization of Hemorrhagic Pneumonia Due to Extraintestinal Pathogenic Escherichia coli in Four Young Dogs. Comparative Medicine. 2003 Dec 1;53(6):663-670.