Clinical and Microbiologic Characterization of Hemorrhagic Pneumonia Due to Extraintestinal Pathogenic Escherichia coli in Four Young Dogs

Larry K. Handt, Dana A. Stoffregen, Judith S. Prescott, Walter J. Pouch, David T.W. Ngai, Charles A. Anderson, Nicholas T. Gatto, Chitrita DebRoy, John M. Fairbrother, Sherri L. Motzel, Hilton J. Klein

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Over a 21-month period, three Beagle dogs and one mixed-breed dog at our facility developed fatal pneumonia. The four dogs, all purpose bred, came from three vendors and had received the standard canine vaccines prior to shipment. In each instance, the affected dog had been shipped to our facility within the past 10 days. Three cases presented as a peracute clinical syndrome, and all had gross and microscopic findings consistent with hemorrhagic pneumonia. Escherichia coli was isolated from the lungs of all four dogs. Results of testing of lung tissue for canine parainfluenza virus and canine adenovirus were negative. Escherichia coli was also isolated from blood of three of the four dogs. Serotyping of the E. coli isolates indicated that two were serotype 06 and two were 04. Isolates from all four dogs were positive for the virulence factors alpha hemolysin and cytotoxic necrotizing factor 1 and for the adhesin factor class-III papG allele. These traits place the isolates in the class of extraintestinal pathogenic E. coli, which is being increasingly implicated as a cause of extraintestinal infections in animals and humans and may represent a zoonotic risk to humans working with research dogs.

Original languageEnglish (US)
Pages (from-to)663-670
Number of pages8
JournalComparative Medicine
Volume53
Issue number6
StatePublished - Dec 2003

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

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    Handt, L. K., Stoffregen, D. A., Prescott, J. S., Pouch, W. J., Ngai, D. T. W., Anderson, C. A., Gatto, N. T., DebRoy, C., Fairbrother, J. M., Motzel, S. L., & Klein, H. J. (2003). Clinical and Microbiologic Characterization of Hemorrhagic Pneumonia Due to Extraintestinal Pathogenic Escherichia coli in Four Young Dogs. Comparative Medicine, 53(6), 663-670.