Clinical management of resistance evolution in a bacterial infection: A case study

Robert J. Woods, Andrew F. Read

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

We report the case of a patient with a chronic bacterial infection that could not be cured. Drug treatment became progressively less effective due to antibiotic resistance, and the patient died, in effect from overwhelming evolution. Even though the evolution of drug resistance was recognized as a major threat, and the fundamentals of drug resistance evolution are well understood, it was impossible to make evidence-based decisions about the evolutionary risks associated with the various treatment options. We present this case to illustrate the urgent need for translational research in the evolutionary medicine of antibiotic resistance.

Original languageEnglish (US)
Article numbereov025
Pages (from-to)281-288
Number of pages8
JournalEvolution, Medicine and Public Health
Volume2015
Issue number1
DOIs
StatePublished - 2015

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Ecology, Evolution, Behavior and Systematics
  • Health, Toxicology and Mutagenesis

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