Clinical models of chemoprevention for colon cancer

K. Krishnan, Mack Ruffin, D. E. Brenner

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Colon cancer is a common malignancy in the westernized world and is incurable in its advanced stages. This article summarizes the currently available information on colorectal cancer chemoprevention. A brief outline of the incidence and etiologic factors is followed by a discussion of the evidence on which chemopreventive strategies for colon cancer are modeled. This includes a description of the development of surrogate endpoint biomarkers and experimental models to study colorectal cancer chemopreventives, a review of the promising colorectal cancer chemopreventives, and a discussion of the issues to be addressed in the design of future chemoprevention trials. The article concludes with an emphasis on the development and validation of biomarkers and selection of high-risk cohorts using genetic and epidemiologic tools as the main goals of future colon cancer chemoprevention trials before large-scale, risk-reduction trials are conducted.

Original languageEnglish (US)
Pages (from-to)1079-1113
Number of pages35
JournalHematology/Oncology Clinics of North America
Volume12
Issue number5
DOIs
StatePublished - Jan 1 1998

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Chemoprevention
Colonic Neoplasms
Colorectal Neoplasms
Biomarkers
Risk Reduction Behavior
Theoretical Models
Incidence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

Cite this

Krishnan, K. ; Ruffin, Mack ; Brenner, D. E. / Clinical models of chemoprevention for colon cancer. In: Hematology/Oncology Clinics of North America. 1998 ; Vol. 12, No. 5. pp. 1079-1113.
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Clinical models of chemoprevention for colon cancer. / Krishnan, K.; Ruffin, Mack; Brenner, D. E.

In: Hematology/Oncology Clinics of North America, Vol. 12, No. 5, 01.01.1998, p. 1079-1113.

Research output: Contribution to journalArticle

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