Clinical outcomes of pulsatile and non-pulsatile mode of perfusion

Nikkole Haines, Shigang Wang, Akif Ündar, Tijen Alkan, Atif Akcevin

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A longstanding debate remains over whether or not pulsatile flow provides better perfusion during cardiopulmonary bypass (CPB). This paper provides a guide for clinical investigation, as well as current laboratory and clinical evidence concerning pulsatile and non-pulsatile perfusion. This evidence is in the form of in vitro and in vivo experiments and clinical trials. We review the literature and provide personal experience from the Pediatric Cardiac Research Laboratories at the Penn State Hershey Children's Hospital. Pulsatility is emerging as the preferred perfusion method for CPB. Clinical evidence show better cardiac, renal, and pulmonary outcomes in patients receiving pulsatile perfusion. Furthermore, better cytokine, endothelin, and hormone levels and a higher respiratory index are shown in pulsatile perfusion modes compared with non-pulsatile perfusion modes. In recent years, evidence has amounted that supports a shift toward pulsatility in these procedures over non-pulsatility. Currently, more evaluation of circuit components and patient outcomes is needed.

Original languageEnglish (US)
Pages (from-to)P26-P29
JournalJournal of Extra-Corporeal Technology
Volume41
Issue number1
StatePublished - Mar 1 2009

Fingerprint

Pulsatile Flow
Perfusion
Cardiopulmonary Bypass
Endothelins
Clinical Trials
Hormones
Pediatrics
Cytokines
Kidney
Lung
Research

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Health Professions (miscellaneous)
  • Cardiology and Cardiovascular Medicine

Cite this

Haines, Nikkole ; Wang, Shigang ; Ündar, Akif ; Alkan, Tijen ; Akcevin, Atif. / Clinical outcomes of pulsatile and non-pulsatile mode of perfusion. In: Journal of Extra-Corporeal Technology. 2009 ; Vol. 41, No. 1. pp. P26-P29.
@article{24b20191960b4f3cb4f6d069a0878f7e,
title = "Clinical outcomes of pulsatile and non-pulsatile mode of perfusion",
abstract = "A longstanding debate remains over whether or not pulsatile flow provides better perfusion during cardiopulmonary bypass (CPB). This paper provides a guide for clinical investigation, as well as current laboratory and clinical evidence concerning pulsatile and non-pulsatile perfusion. This evidence is in the form of in vitro and in vivo experiments and clinical trials. We review the literature and provide personal experience from the Pediatric Cardiac Research Laboratories at the Penn State Hershey Children's Hospital. Pulsatility is emerging as the preferred perfusion method for CPB. Clinical evidence show better cardiac, renal, and pulmonary outcomes in patients receiving pulsatile perfusion. Furthermore, better cytokine, endothelin, and hormone levels and a higher respiratory index are shown in pulsatile perfusion modes compared with non-pulsatile perfusion modes. In recent years, evidence has amounted that supports a shift toward pulsatility in these procedures over non-pulsatility. Currently, more evaluation of circuit components and patient outcomes is needed.",
author = "Nikkole Haines and Shigang Wang and Akif {\"U}ndar and Tijen Alkan and Atif Akcevin",
year = "2009",
month = "3",
day = "1",
language = "English (US)",
volume = "41",
pages = "P26--P29",
journal = "Journal of Extra-Corporeal Technology",
issn = "0022-1058",
publisher = "American Society of Extra-Corporeal Technology",
number = "1",

}

Haines, N, Wang, S, Ündar, A, Alkan, T & Akcevin, A 2009, 'Clinical outcomes of pulsatile and non-pulsatile mode of perfusion', Journal of Extra-Corporeal Technology, vol. 41, no. 1, pp. P26-P29.

Clinical outcomes of pulsatile and non-pulsatile mode of perfusion. / Haines, Nikkole; Wang, Shigang; Ündar, Akif; Alkan, Tijen; Akcevin, Atif.

In: Journal of Extra-Corporeal Technology, Vol. 41, No. 1, 01.03.2009, p. P26-P29.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical outcomes of pulsatile and non-pulsatile mode of perfusion

AU - Haines, Nikkole

AU - Wang, Shigang

AU - Ündar, Akif

AU - Alkan, Tijen

AU - Akcevin, Atif

PY - 2009/3/1

Y1 - 2009/3/1

N2 - A longstanding debate remains over whether or not pulsatile flow provides better perfusion during cardiopulmonary bypass (CPB). This paper provides a guide for clinical investigation, as well as current laboratory and clinical evidence concerning pulsatile and non-pulsatile perfusion. This evidence is in the form of in vitro and in vivo experiments and clinical trials. We review the literature and provide personal experience from the Pediatric Cardiac Research Laboratories at the Penn State Hershey Children's Hospital. Pulsatility is emerging as the preferred perfusion method for CPB. Clinical evidence show better cardiac, renal, and pulmonary outcomes in patients receiving pulsatile perfusion. Furthermore, better cytokine, endothelin, and hormone levels and a higher respiratory index are shown in pulsatile perfusion modes compared with non-pulsatile perfusion modes. In recent years, evidence has amounted that supports a shift toward pulsatility in these procedures over non-pulsatility. Currently, more evaluation of circuit components and patient outcomes is needed.

AB - A longstanding debate remains over whether or not pulsatile flow provides better perfusion during cardiopulmonary bypass (CPB). This paper provides a guide for clinical investigation, as well as current laboratory and clinical evidence concerning pulsatile and non-pulsatile perfusion. This evidence is in the form of in vitro and in vivo experiments and clinical trials. We review the literature and provide personal experience from the Pediatric Cardiac Research Laboratories at the Penn State Hershey Children's Hospital. Pulsatility is emerging as the preferred perfusion method for CPB. Clinical evidence show better cardiac, renal, and pulmonary outcomes in patients receiving pulsatile perfusion. Furthermore, better cytokine, endothelin, and hormone levels and a higher respiratory index are shown in pulsatile perfusion modes compared with non-pulsatile perfusion modes. In recent years, evidence has amounted that supports a shift toward pulsatility in these procedures over non-pulsatility. Currently, more evaluation of circuit components and patient outcomes is needed.

UR - http://www.scopus.com/inward/record.url?scp=68549087099&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68549087099&partnerID=8YFLogxK

M3 - Article

C2 - 19361037

AN - SCOPUS:68549087099

VL - 41

SP - P26-P29

JO - Journal of Extra-Corporeal Technology

JF - Journal of Extra-Corporeal Technology

SN - 0022-1058

IS - 1

ER -