Clinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care

Yi Wang, Pascal Spincemaille, Zhe Liu, Alexey Dimov, Kofi Deh, Jianqi Li, Yan Zhang, Yihao Yao, Kelly M. Gillen, Alan H. Wilman, Ajay Gupta, Apostolos John Tsiouris, Ilhami Kovanlikaya, Gloria Chia Yi Chiang, Jonathan W. Weinsaft, Lawrence Tanenbaum, Weiwei Chen, Wenzhen Zhu, Shixin Chang, Min LouBrian H. Kopell, Michael G. Kaplitt, David Devos, Toshinori Hirai, Xuemei Huang, Yukunori Korogi, Alexander Shtilbans, Geon Ho Jahng, Daniel Pelletier, Susan A. Gauthier, David Pitt, Ashley I. Bush, Gary M. Brittenham, Martin R. Prince

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

Quantitative susceptibility mapping (QSM) has enabled magnetic resonance imaging (MRI) of tissue magnetic susceptibility to advance from simple qualitative detection of hypointense blooming artifacts to precise quantitative measurement of spatial biodistributions. QSM technology may be regarded to be sufficiently developed and validated to warrant wide dissemination for clinical applications of imaging isotropic susceptibility, which is dominated by metals in tissue, including iron and calcium. These biometals are highly regulated as vital participants in normal cellular biochemistry, and their dysregulations are manifested in a variety of pathologic processes. Therefore, QSM can be used to assess important tissue functions and disease. To facilitate QSM clinical translation, this review aims to organize pertinent information for implementing a robust automated QSM technique in routine MRI practice and to summarize available knowledge on diseases for which QSM can be used to improve patient care. In brief, QSM can be generated with postprocessing whenever gradient echo MRI is performed. QSM can be useful for diseases that involve neurodegeneration, inflammation, hemorrhage, abnormal oxygen consumption, substantial alterations in highly paramagnetic cellular iron, bone mineralization, or pathologic calcification; and for all disorders in which MRI diagnosis or surveillance requires contrast agent injection. Clinicians may consider integrating QSM into their routine imaging practices by including gradient echo sequences in all relevant MRI protocols. Level of Evidence: 1. Technical Efficacy: Stage 5. J. Magn. Reson. Imaging 2017;46:951–971.

Original languageEnglish (US)
Pages (from-to)951-971
Number of pages21
JournalJournal of Magnetic Resonance Imaging
Volume46
Issue number4
DOIs
StatePublished - Oct 2017

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Trace Elements
Patient Care
Magnetic Resonance Imaging
Iron
Calcinosis
Physiologic Calcification
Pathologic Processes
Oxygen Consumption
Biochemistry
Artifacts
Contrast Media
Metals
Hemorrhage
Inflammation
Calcium
Technology
Injections

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Wang, Yi ; Spincemaille, Pascal ; Liu, Zhe ; Dimov, Alexey ; Deh, Kofi ; Li, Jianqi ; Zhang, Yan ; Yao, Yihao ; Gillen, Kelly M. ; Wilman, Alan H. ; Gupta, Ajay ; Tsiouris, Apostolos John ; Kovanlikaya, Ilhami ; Chiang, Gloria Chia Yi ; Weinsaft, Jonathan W. ; Tanenbaum, Lawrence ; Chen, Weiwei ; Zhu, Wenzhen ; Chang, Shixin ; Lou, Min ; Kopell, Brian H. ; Kaplitt, Michael G. ; Devos, David ; Hirai, Toshinori ; Huang, Xuemei ; Korogi, Yukunori ; Shtilbans, Alexander ; Jahng, Geon Ho ; Pelletier, Daniel ; Gauthier, Susan A. ; Pitt, David ; Bush, Ashley I. ; Brittenham, Gary M. ; Prince, Martin R. / Clinical quantitative susceptibility mapping (QSM) : Biometal imaging and its emerging roles in patient care. In: Journal of Magnetic Resonance Imaging. 2017 ; Vol. 46, No. 4. pp. 951-971.
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abstract = "Quantitative susceptibility mapping (QSM) has enabled magnetic resonance imaging (MRI) of tissue magnetic susceptibility to advance from simple qualitative detection of hypointense blooming artifacts to precise quantitative measurement of spatial biodistributions. QSM technology may be regarded to be sufficiently developed and validated to warrant wide dissemination for clinical applications of imaging isotropic susceptibility, which is dominated by metals in tissue, including iron and calcium. These biometals are highly regulated as vital participants in normal cellular biochemistry, and their dysregulations are manifested in a variety of pathologic processes. Therefore, QSM can be used to assess important tissue functions and disease. To facilitate QSM clinical translation, this review aims to organize pertinent information for implementing a robust automated QSM technique in routine MRI practice and to summarize available knowledge on diseases for which QSM can be used to improve patient care. In brief, QSM can be generated with postprocessing whenever gradient echo MRI is performed. QSM can be useful for diseases that involve neurodegeneration, inflammation, hemorrhage, abnormal oxygen consumption, substantial alterations in highly paramagnetic cellular iron, bone mineralization, or pathologic calcification; and for all disorders in which MRI diagnosis or surveillance requires contrast agent injection. Clinicians may consider integrating QSM into their routine imaging practices by including gradient echo sequences in all relevant MRI protocols. Level of Evidence: 1. Technical Efficacy: Stage 5. J. Magn. Reson. Imaging 2017;46:951–971.",
author = "Yi Wang and Pascal Spincemaille and Zhe Liu and Alexey Dimov and Kofi Deh and Jianqi Li and Yan Zhang and Yihao Yao and Gillen, {Kelly M.} and Wilman, {Alan H.} and Ajay Gupta and Tsiouris, {Apostolos John} and Ilhami Kovanlikaya and Chiang, {Gloria Chia Yi} and Weinsaft, {Jonathan W.} and Lawrence Tanenbaum and Weiwei Chen and Wenzhen Zhu and Shixin Chang and Min Lou and Kopell, {Brian H.} and Kaplitt, {Michael G.} and David Devos and Toshinori Hirai and Xuemei Huang and Yukunori Korogi and Alexander Shtilbans and Jahng, {Geon Ho} and Daniel Pelletier and Gauthier, {Susan A.} and David Pitt and Bush, {Ashley I.} and Brittenham, {Gary M.} and Prince, {Martin R.}",
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Wang, Y, Spincemaille, P, Liu, Z, Dimov, A, Deh, K, Li, J, Zhang, Y, Yao, Y, Gillen, KM, Wilman, AH, Gupta, A, Tsiouris, AJ, Kovanlikaya, I, Chiang, GCY, Weinsaft, JW, Tanenbaum, L, Chen, W, Zhu, W, Chang, S, Lou, M, Kopell, BH, Kaplitt, MG, Devos, D, Hirai, T, Huang, X, Korogi, Y, Shtilbans, A, Jahng, GH, Pelletier, D, Gauthier, SA, Pitt, D, Bush, AI, Brittenham, GM & Prince, MR 2017, 'Clinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care', Journal of Magnetic Resonance Imaging, vol. 46, no. 4, pp. 951-971. https://doi.org/10.1002/jmri.25693

Clinical quantitative susceptibility mapping (QSM) : Biometal imaging and its emerging roles in patient care. / Wang, Yi; Spincemaille, Pascal; Liu, Zhe; Dimov, Alexey; Deh, Kofi; Li, Jianqi; Zhang, Yan; Yao, Yihao; Gillen, Kelly M.; Wilman, Alan H.; Gupta, Ajay; Tsiouris, Apostolos John; Kovanlikaya, Ilhami; Chiang, Gloria Chia Yi; Weinsaft, Jonathan W.; Tanenbaum, Lawrence; Chen, Weiwei; Zhu, Wenzhen; Chang, Shixin; Lou, Min; Kopell, Brian H.; Kaplitt, Michael G.; Devos, David; Hirai, Toshinori; Huang, Xuemei; Korogi, Yukunori; Shtilbans, Alexander; Jahng, Geon Ho; Pelletier, Daniel; Gauthier, Susan A.; Pitt, David; Bush, Ashley I.; Brittenham, Gary M.; Prince, Martin R.

In: Journal of Magnetic Resonance Imaging, Vol. 46, No. 4, 10.2017, p. 951-971.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Clinical quantitative susceptibility mapping (QSM)

T2 - Biometal imaging and its emerging roles in patient care

AU - Wang, Yi

AU - Spincemaille, Pascal

AU - Liu, Zhe

AU - Dimov, Alexey

AU - Deh, Kofi

AU - Li, Jianqi

AU - Zhang, Yan

AU - Yao, Yihao

AU - Gillen, Kelly M.

AU - Wilman, Alan H.

AU - Gupta, Ajay

AU - Tsiouris, Apostolos John

AU - Kovanlikaya, Ilhami

AU - Chiang, Gloria Chia Yi

AU - Weinsaft, Jonathan W.

AU - Tanenbaum, Lawrence

AU - Chen, Weiwei

AU - Zhu, Wenzhen

AU - Chang, Shixin

AU - Lou, Min

AU - Kopell, Brian H.

AU - Kaplitt, Michael G.

AU - Devos, David

AU - Hirai, Toshinori

AU - Huang, Xuemei

AU - Korogi, Yukunori

AU - Shtilbans, Alexander

AU - Jahng, Geon Ho

AU - Pelletier, Daniel

AU - Gauthier, Susan A.

AU - Pitt, David

AU - Bush, Ashley I.

AU - Brittenham, Gary M.

AU - Prince, Martin R.

PY - 2017/10

Y1 - 2017/10

N2 - Quantitative susceptibility mapping (QSM) has enabled magnetic resonance imaging (MRI) of tissue magnetic susceptibility to advance from simple qualitative detection of hypointense blooming artifacts to precise quantitative measurement of spatial biodistributions. QSM technology may be regarded to be sufficiently developed and validated to warrant wide dissemination for clinical applications of imaging isotropic susceptibility, which is dominated by metals in tissue, including iron and calcium. These biometals are highly regulated as vital participants in normal cellular biochemistry, and their dysregulations are manifested in a variety of pathologic processes. Therefore, QSM can be used to assess important tissue functions and disease. To facilitate QSM clinical translation, this review aims to organize pertinent information for implementing a robust automated QSM technique in routine MRI practice and to summarize available knowledge on diseases for which QSM can be used to improve patient care. In brief, QSM can be generated with postprocessing whenever gradient echo MRI is performed. QSM can be useful for diseases that involve neurodegeneration, inflammation, hemorrhage, abnormal oxygen consumption, substantial alterations in highly paramagnetic cellular iron, bone mineralization, or pathologic calcification; and for all disorders in which MRI diagnosis or surveillance requires contrast agent injection. Clinicians may consider integrating QSM into their routine imaging practices by including gradient echo sequences in all relevant MRI protocols. Level of Evidence: 1. Technical Efficacy: Stage 5. J. Magn. Reson. Imaging 2017;46:951–971.

AB - Quantitative susceptibility mapping (QSM) has enabled magnetic resonance imaging (MRI) of tissue magnetic susceptibility to advance from simple qualitative detection of hypointense blooming artifacts to precise quantitative measurement of spatial biodistributions. QSM technology may be regarded to be sufficiently developed and validated to warrant wide dissemination for clinical applications of imaging isotropic susceptibility, which is dominated by metals in tissue, including iron and calcium. These biometals are highly regulated as vital participants in normal cellular biochemistry, and their dysregulations are manifested in a variety of pathologic processes. Therefore, QSM can be used to assess important tissue functions and disease. To facilitate QSM clinical translation, this review aims to organize pertinent information for implementing a robust automated QSM technique in routine MRI practice and to summarize available knowledge on diseases for which QSM can be used to improve patient care. In brief, QSM can be generated with postprocessing whenever gradient echo MRI is performed. QSM can be useful for diseases that involve neurodegeneration, inflammation, hemorrhage, abnormal oxygen consumption, substantial alterations in highly paramagnetic cellular iron, bone mineralization, or pathologic calcification; and for all disorders in which MRI diagnosis or surveillance requires contrast agent injection. Clinicians may consider integrating QSM into their routine imaging practices by including gradient echo sequences in all relevant MRI protocols. Level of Evidence: 1. Technical Efficacy: Stage 5. J. Magn. Reson. Imaging 2017;46:951–971.

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U2 - 10.1002/jmri.25693

DO - 10.1002/jmri.25693

M3 - Review article

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