Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants

Carmen D. Zorrilla, Russell Van Dyke, Arlene Bardeguez, Edward P. Acosta, Betsy Smith, Michael D. Hughes, Sharon Huang, D. Heather Watts, Barbara Heckman, Eleanor Jiménez, George McSherry, Lynne Mofenson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Saquinavir boosted with low-dose ritonavir given with zidovudine and lamivudine was well tolerated by pregnant women and their infants. All mothers had <400 human immunodeficiency virus type 1 RNA copies/ml at delivery. Two had elevated liver transaminases and amylase. Seven infant adverse events were possibly treatment related (anemia, neutropenia, and hyperbilirubinemia).

Original languageEnglish (US)
Pages (from-to)2208-2210
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number6
DOIs
StatePublished - Jun 1 2007

Fingerprint

Saquinavir
Ritonavir
HIV-1
Mothers
Safety
Hyperbilirubinemia
Lamivudine
Zidovudine
Amylases
Transaminases
Neutropenia
Anemia
Pregnant Women
RNA
Liver
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Zorrilla, Carmen D. ; Van Dyke, Russell ; Bardeguez, Arlene ; Acosta, Edward P. ; Smith, Betsy ; Hughes, Michael D. ; Huang, Sharon ; Watts, D. Heather ; Heckman, Barbara ; Jiménez, Eleanor ; McSherry, George ; Mofenson, Lynne. / Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants. In: Antimicrobial agents and chemotherapy. 2007 ; Vol. 51, No. 6. pp. 2208-2210.
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Zorrilla, CD, Van Dyke, R, Bardeguez, A, Acosta, EP, Smith, B, Hughes, MD, Huang, S, Watts, DH, Heckman, B, Jiménez, E, McSherry, G & Mofenson, L 2007, 'Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants', Antimicrobial agents and chemotherapy, vol. 51, no. 6, pp. 2208-2210. https://doi.org/10.1128/AAC.00871-06

Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants. / Zorrilla, Carmen D.; Van Dyke, Russell; Bardeguez, Arlene; Acosta, Edward P.; Smith, Betsy; Hughes, Michael D.; Huang, Sharon; Watts, D. Heather; Heckman, Barbara; Jiménez, Eleanor; McSherry, George; Mofenson, Lynne.

In: Antimicrobial agents and chemotherapy, Vol. 51, No. 6, 01.06.2007, p. 2208-2210.

Research output: Contribution to journalArticle

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AU - Zorrilla, Carmen D.

AU - Van Dyke, Russell

AU - Bardeguez, Arlene

AU - Acosta, Edward P.

AU - Smith, Betsy

AU - Hughes, Michael D.

AU - Huang, Sharon

AU - Watts, D. Heather

AU - Heckman, Barbara

AU - Jiménez, Eleanor

AU - McSherry, George

AU - Mofenson, Lynne

PY - 2007/6/1

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