Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants

Carmen D. Zorrilla, Russell Van Dyke, Arlene Bardeguez, Edward P. Acosta, Betsy Smith, Michael D. Hughes, Sharon Huang, D. Heather Watts, Barbara Heckman, Eleanor Jiménez, George McSherry, Lynne Mofenson

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Saquinavir boosted with low-dose ritonavir given with zidovudine and lamivudine was well tolerated by pregnant women and their infants. All mothers had <400 human immunodeficiency virus type 1 RNA copies/ml at delivery. Two had elevated liver transaminases and amylase. Seven infant adverse events were possibly treatment related (anemia, neutropenia, and hyperbilirubinemia).

Original languageEnglish (US)
Pages (from-to)2208-2210
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number6
DOIs
StatePublished - Jun 2007

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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