Clinical risk factors demonstrate an age-dependent relationship with oxidative stress biomarkers in African Americans

Kathleen Sturgeon, Deborah L. Feairheller, Keith M. Diaz, Sheara T. Williamson, Praveen Veerabhadrappa, Michael D. Brown

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Objective: To examine the interaction of oxidative stress biomarkers with age, and also factors that influence oxidative stress such as body mass index (BMI) and fitness in a population of individuals with established higher risk of cardiovascular disease, African Americans. Methods: Blood samples were obtained from healthy college-age and middle-age to older African Americans. Participants underwent a graded exercise test. Superoxide dismutase (SOD) activity, total antioxidant capacity and thiobarbituric acid reactive substances (TBARS) levels were measured. Results: TBARS levels were significantly (P=.001) lower in young participants relative to middle-age to older participants. SOD activity was significantly (P=.001) lower in middle-age to older participants with low fitness relative to participants with normal fitness, and lower (P=.04) in middle-age to older participants that were overweight relative to normal weight participants. Discussion: In a healthy middle-age to older population of African Americans, BMI and fitness are crucial for maintaining a healthy endothelium.

Original languageEnglish (US)
Pages (from-to)403-408
Number of pages6
JournalEthnicity and Disease
Volume20
Issue number4
StatePublished - Sep 1 2010

All Science Journal Classification (ASJC) codes

  • Epidemiology

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