Clinical significance of viable-enriched circulating tumor cells with a flexible micro spring array

R. Harouaka, X. Liu, W. Khan, T. Khan, S. Rice, C. Belani, S. Y. Zheng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Circulating tumor cells (CTCs) in peripheral blood are implicated in the spread of cancer by metastasis. CTCs are associated with worse survival and have been demonstrated as a prognostic biomarker in various cancer types. We have developed a flexible micro spring array (FMSA) device for antigen-independent viable-enrichment of CTCs from whole blood based on cell size and deformability. CTCs were enriched from twenty blood samples obtained from advanced non-small cell lung cancer (NSCLC) patients and quantified through immunocytochemical detection. CTC detection was correlated to a significant decrease in patient survival demonstrating the clinical relevance of FMSA-enriched CTCs in NSCLC.

Original languageEnglish (US)
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages579-581
Number of pages3
ISBN (Electronic)9780979806476
StatePublished - Jan 1 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period10/26/1410/30/14

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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  • Cite this

    Harouaka, R., Liu, X., Khan, W., Khan, T., Rice, S., Belani, C., & Zheng, S. Y. (2014). Clinical significance of viable-enriched circulating tumor cells with a flexible micro spring array. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 579-581). (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014). Chemical and Biological Microsystems Society.